超声波技术合成2,5,2'5'-四(二甲氨基甲基)-4,4'-二羟基二苯醚  

Synthesis of 2,5,2',5'-Tetra (trimethylaminemethylene)-4,4'-Dihydroxydiphenyl Ether Using Ultrasonic Technique

作　　者：李香丹[1] 官树猛 何思威 李海[1] 李立忠[1] 申凤善[2] Li Xiangdan Guan Shumeng He Siwei Li Hai Li Lizhong Shen Fengshan(College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074, China College of Science,Yanbian University, Yanji 133400,China)

机构地区：[1]中南民族大学化学与材料科学学院,武汉430074 [2]延边大学理学院,延吉133002

出　　处：《中南民族大学学报（自然科学版）》2017年第1期5-7,共3页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：国家自然科学基金资助项目(51243005)

摘　　要：采用超声技术,以4,4'-二羟基二苯醚、质量比分别为33%二甲胺和37%甲醛水溶液为原料,无水乙醇为溶剂,N2保护下,经Mannich反应合成了2,5,2'5'-四(二甲氨基甲基)-4,4'-二羟基二苯醚,产物结构经1H NMR,FTIR进行了表征.结果表明:4,4'-二羟基二苯醚、二甲胺和甲醛的摩尔比为1︰10︰10,60℃下反应60 min时产率最高,可达92.1%,较传统方法反应时间短、反应温度低、后处理简单、产率高.2,5,2＇,5＇-tetra（trimethylaminemethylene）-4,4＇-dihydroxydiphenyl ether was synthesized by the reaction of 4,4＇-dihydroxydiphenyl ether,dimethylamine aqueous solution（mass ratio 33%） and formaldehyde（mass ratio 37%） in ethanol via Mannich reaction under sonication and N2 atmosphere. The structure of the product was confirmed by1 H NMR and FT-IR,and the highest yield reached 92. 1% when the molar ratio of 4,4＇-dihydroxydiphenyl ether,dimethylamine and formaldehyde was adjusted to 1 ： 10 ： 10 and then reacted for 60 min at 60 ℃. Compared with the traditional methods,our strategy showed advantages of short reaction time,low reaction temperature,simple operation and high yield.

关 键 词：2 5 2′5′-四（二甲氨基甲基）-4 4′-二羟基二苯醚 超声波 合成 

分 类 号：O625[理学—有机化学] TQ203.9[理学—化学]