降钙素缓释剂髓腔内植入对大鼠骨质疏松的影响  

The effect of sustained-release salmon calcitonin on rat osteoporosis

作　　者：虞陆超 李海旭[1] 刘孚瑛[1] 石文俊[1] 周强[1] 石继祥[1] 

机构地区：[1]上海中医药大学附属普陀医院骨科,200333

出　　处：《国际骨科学杂志》2017年第2期121-124,共4页International Journal of Orthopaedics

摘　　要：目的探讨降钙素缓释剂髓腔内植入对大鼠全身骨质疏松的影响。方法将40只3月龄的雌性SD大鼠随机分为4组,A组为卵巢切除联合低剂量降钙素组,B组为卵巢切除联合高剂量降钙素组,C组为卵巢切除联合空白磷酸钙载体组,D组为假手术组,每组各10只,比较植入术后2、4、8周各组血钙和全身骨密度变化。结果植入术后8周,与C组相比,A组和B组股骨近端骨密度均有显著改善(P<0.05),A组和B组血钙浓度较C组显著下降(P<0.05)。结论降钙素缓释剂髓腔内植入可在大鼠体内稳定有效地释放降钙素,降低血钙,提高骨密度。Objective To evaluate the effect of intramedullary implantation of sustained-release salmon calcitonin on systemic osteoporosis of rats.Methods A total of 40 female SD rats aged 3 months were randomly divided into four groups：ovariectomized rats treated with low dose of calcitonin（Group A）,ovariectomized rats treated with high dose of calcitonin（Group B）,ovariectomized rats treated only with calcium phosphate carrier（Group C）,and sham operation（Group D）,with10 rats in each group.Bone mineral density and serum calcium concentration were compared among the 4 groups at 2,4,and 8 weeks after the operation.Results At 8 weeks after the operation,compared with Group C,the bone density at the proximal femur was improved significantly（P〈0.05）and the level of serum calcium was reduced significantly in Group A and Group B（P〈0.05）.Conclusion Intramedullary implantation of sustained-release salmon calcitonin can release the calcitonin in rats in an effective and stable manner to improve bone density and reduce serum calcium.

关 键 词：骨质疏松 降钙素 磷酸钙骨水泥 缓释 

分 类 号：R580[医药卫生—内分泌]