甲泼尼龙联合射干麻黄汤治疗小儿哮喘的临床疗效及安全性研究  

Research on Clinical Curative Effect and Safety of Methylprednisolone and Belamcanda and Ephedra Decoction in Treatment of Asthma in Children

作　　者：张雪医 张丽文[1] 白明辉[1] 亢杨[1] 戴春晖[1] 

机构地区：[1]黑龙江省齐齐哈尔市齐齐哈尔医学院附属第三医院儿科,黑龙江齐齐哈尔161000

出　　处：《中外医疗》2017年第4期115-116,119,共3页China & Foreign Medical Treatment

基　　金：齐齐哈尔市科学技术计划项目(SFZD-2015038)

摘　　要：目的探讨甲泼尼龙注射液联合射干麻黄汤治疗小儿哮喘的有效性及安全性。方法方便收集齐齐哈尔医学院附属第三医院2014年1月—2016年3月收治的儿科哮喘患儿42例,分为联合组(24例)与甲泼尼龙组(18例),30例正常哮喘患儿作对照组。对症支持治疗后,联合组采用两种药物联合,甲泼尼龙组采用甲泼尼龙。7 d后评价疗效,身高体重及骨密度进行安全性分析。结果 (1)联合组与甲泼尼龙组总有效率为91.67%和61.11%,差异有统计学意义(P<0.05),联合组高于甲泼尼龙组。(2)联合组与对照组身高增加为(5.92±0.98)、(6.15±1.31)cm,体重增加为(1.48±0.34)、(1.64±0.49)kg,骨密度为(0.43±0.02)、(0.45±0.06)g/cm2。两组身高及体重增加、骨密度之间的差异无统计学意义(P>0.05)。(3)联合组与对照组复发率为20.83%、23.33%,差异无统计学意义(P>0.05)。结论甲泼尼龙与射干麻黄汤联合能够控制小儿哮喘的发作,安全性能得到保障。Objective To study the clinical curative effect and safety of methylprednisolone and belamcanda and ephedra decoction in treatment of asthma in children. Methods Convenient selection 42 cases of children with asthma in the department of paediatrics from January 2014 to March 2016 were collected and divided into the combined group（24 cases） and methylprednisolone group（18 cases）, and 30 cases of normal asthma children were used as the control group, after the symptomatic support treatment, the combined group were treated with the combined drugs, while the methylprednisolone group were treated with methylprednisolone, and the curative effect was evaluated after 7d, and the height, weight and bone density were given the safety analysis. Results（1）The difference in the total effective rate between the combined group and the methylprednisolone group had statistical significance（91.67% vs 61.11%）（P〈0.05）.（2）The differences in the height increase, weight increase and bone density between the combined group and control group had no statistical significance[（5.92±0.98）cm,（1.48±0.34）kg,（0.43±0.02）g/cm^2vs（6.15±1.31）cm,（1.64±0.49）kg,（0.45±0.06）g/cm^2]（P〉0.05）.（3）The difference in the recurrence rate between the combined group and the control group had no statistical significance（20.83% vs23.33%）（P〉0.05）. Conclusion Methylprednisolone and belamcanda and ephedra decoction can effectively control the attack of asthma in children and ensure the safety.

关 键 词：甲泼尼龙 射干麻黄汤 小儿哮喘 疗效 安全性 

分 类 号：R272[医药卫生—中医儿科学]