抗肿瘤干细胞活性物质研究进展  

Research progress on the chemicals with cancer stem cell growth inhibitory activity

作　　者：李娇[1] 汤华[1] 庄春林[1] 孙鹏[1] 马福家[2] 张文[1] 

机构地区：[1]第二军医大学药学院海洋药物研究中心/海洋生物医药研究所,上海200433 [2]解放军455医院药剂科,上海200052

出　　处：《中国生化药物杂志》2017年第3期20-26,共7页Chinese Journal of Biochemical Pharmaceutics

基　　金：国家自然基金(41576157);上海市优秀学科带头人计划(15XD1504600)

摘　　要：肿瘤干细胞是肿瘤侵袭、转移、复发及耐药的关键因素,寻找新型抗肿瘤干细胞药用活性物质已经成为抗肿瘤药物研究的热点。本文对近来抗肿瘤干细胞活性物质研究进展进行了综述,以期为抗肿瘤活性物质研究提供参考。Cancer stem cells play a crucial role in tumors＇invasion, metastasis, recurrence and drug resistance.Investigation on the chemicals with tumor stem cell growth inhibitory activity has been greatly highlighted in the field of anti-tumor drug discovery.This paper briefly reviews the recent progress of chemical investigations on substances with tumor stem cell growth inhibitory activity , aiming to give readers a reference on anti-tumor drug discovery.

关 键 词：肿瘤干细胞 生长抑制活性 活性物质 

分 类 号：R931.77[医药卫生—生药学]