百蕊胶囊联合阿奇霉素治疗支原体肺炎的疗效及对患儿血清hs-CRP、EC、SIL-2R的影响  

Effect of Bairui capsule combined with azithromycin in the treatment of mycoplasma pneumonia and its effect on serum hs-CRP, EC and SIL-2R

作　　者：姜文涛 褚亚苏 王剑 

机构地区：[1]余姚市第二人民医院儿科

出　　处：《中国生化药物杂志》2017年第3期128-130,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 观察百蕊胶囊联合阿奇霉素治疗支原体肺炎的疗效及对患儿血清超敏C反应蛋白（hs-CRP）、嗜酸性粒细胞（EC）、可溶性白细胞介素-2（SIL-2R）的影响。方法 选取2015年8月～2016年7月余姚市第二人民医院收治的86例支原体肺炎患儿,随机分为观察组和对照组,每组43例。对照组给予阿奇霉素治疗,观察组在对照组基础上给予百蕊胶囊。比较2组患儿临床疗效,症状及体征消失时间,血清hs-CRP、EC、SIL-2R水平变化及不良反应发生率。结果 观察组临床总有效率显著高于对照组[90.70%（39/43）比67.44%（29/43）],差异具有统计学意义（P〈0.05）。观察组的肺部啰音消失时间、咳嗽消失时间、退热时间、X线胸片恢复时间显著短于对照组,差异均具有统计学意义（P〈0.05）。观察组血清hs-CRP、EC、SIL-2R水平低于对照组,差异均具有统计学意义（P〈0.05）。2组不良反应率比较差异无统计学意义。结论 百蕊胶囊联合阿奇霉素治疗支原体肺炎患儿临床疗效良好,能有效降低患儿血清hs-CRP、EC、SIL-2R水平,且不良反应率低。Objective To study the curative effect of Bairui capsule combined with azithromycin in treatment of children with mycoplasmal pneumonia and its effect on serum high sensitive C-reactive protein, eosinophil, soluble interleukin-2.Methods 86 patients with mycoplasma pneumonia were enrolled from August 2015 to July 2016 in our hospital.According to the order of admission, the patients were divided into observation group and control group.The control group was treated with azithromycin , and the observation group was treated with Bairui capsule and azithromycin.Clinical efficacy,symptoms and signs of disappearance of time, CRP, EC, SIL-2R and adverse reaction rate were compared between the two groups.Results The total effective rate in the observation group was significantly higher than the control group [90.70% （39/43） vs 67.44% （29/43）]（P〈0.05）.The time of disappearance of lung rales, the disappearance time of cough, the time of fever and the recovery time of X -ray in the observation group were significantly shorter than the control group （P〈0.05）.The levels of serum hs-CRP, EC and SIL-2R in the observation group were lower than the control group （P〈0.05） .There was no significant difference in adverse reaction rate between observation group and control group.Conclusion Bai Rui capsule combined with azithromycin in children with mycoplasma pneumonia can effectively reduce the serum hs-CRP, EC, SIL-2R levels, clinical efficacy is good, low adverse reaction rate.

关 键 词：百蕊胶囊 阿奇霉素 支原体肺炎 超敏C反应蛋白 嗜酸性粒细胞 可溶性白细胞介素-2 

分 类 号：R725.4[医药卫生—儿科]