地佐辛用于腹腔镜阑尾术患者的临床效果及对白细胞计数和C反应蛋白的影响  

Curative efficacy of Dezocine in treatment of receiving laparoscopic appendectomy and its effects on white blood cell count and C reactive protein

作　　者：袁飞[1] 金原野[1] 周金萍[1] 刘冬炎[1] 蔡璐[1] 

机构地区：[1]绍兴第二医院麻醉科

出　　处：《中国生化药物杂志》2017年第3期231-233,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 研究地佐辛用于腹腔镜阑尾术患者的临床效果及对白细胞计数和C反应蛋白的影响。方法 选取2015年1月～2016年10月绍兴第二医院接诊的90例行腹腔镜阑尾术患者作为研究对象,按照随机数表法分为观察组和对照组,每组各45例,对照组采用舒芬太尼治疗,观察组采用地佐辛治疗。观察2患者手术指标,T0（术前）、T1（拔管时）、T2（拔管后）各时间点平均动脉压（MAP）、心率（HR）及呼吸次数（RR）变化,比较视觉模拟评分（VAS）、镇静评分（RSS）,白细胞计数、C反应蛋白水平。结果 治疗后,观察组T1、T2时,MAP、HR显著小于对照组[（78.30±6.20）mm Hg vs（86.08±6.09）mm Hg,（76.45±5.90）mm Hg vs.（80.48±5.80）mm Hg,（90.82±9.50）次/min vs.（96.73±9.83）次/min,（87.21±8.15）次/min vs.（93.59±9.90）次/min]（P〈0.05）;VAS、RSS评分均显著小于对照组[（2.60±0.70）分vs.（5.29±0.83）分,（3.53±0.92）分vs.（6.38±1.21）分]（P〈0.05）;白细胞计数、C反应蛋白显著低于对照组[（7.92±2.01）×109/L vs.（14.98±2.11）×109/L、（7.90±2.30）mg/L vs（12.46±3.10）mg/L]（P〈0.05）。结论 地佐辛用于腹腔镜阑尾术患者的临床镇痛效果显著,可显著的降低白细胞计数和C反应蛋白水平。Objective To study curative efficacy of dezocine in treatment of receiving laparoscopic appendectomy and its effects on white blood cell count and c reactive protein.Methods 90 patients of laparoscopic appendectomy who received therapy from January 2015 to October 2016 in our hospital were selected as research objects,according to random number table,those patients were divided into the observation group and the control group,45 cases in each group.The control group was treated with sufentanil, while the observation group was treated with dezocine.Then operation index, T0 （preoperative）,T1（extubation）,T2（after extubation） mean arterial pressure（MAP）,heart rate（HR）, respiration rate（RR）,isual analogue scale/score （ VAS） , ramsay score （ RSS） , white blood cell count and c reactive protein of two groups after treatment were compared .Results After treatment, MAP,HR in the observation group were significantly lower than control group [（78.30 ±6.20）mmHg vs.（86.08 ±6.09）mmHg,（76.45 ±5.90）mmHg vs.（80.48 ±5.80）mmHg,（90.82 ±9.50）time/min vs.（96.73 ±9.83）time /min,（87.21 ±8.15）time /min vs.（93.59 ±9.90）time /min]（P〈0.05）; VAS, RSS score were significantly lower than the control group[（2.60 ±0.70）score vs.（5.29 ±0.83）score,（3.53 ±0.92）score vs.（6.38 ± 1.21）score]（P〈0.05）; White blood cell count, c reactive protein were significantly lower than the control group[（7.92 ±2.01） ×109/L vs.（14.98 ±2.11） ×109/L,（7.90 ±2.30）mg/L vs（12.46 ±3.10）mg/L]（P〈0.05）.Conclusion Dezocine is well for receiving laparoscopic appendectomy, obvious analgesic effect, can significantly reduce the white blood cell count and c reactive protein.

关 键 词：地佐辛 腹腔镜阑尾术 白细胞计数 C反应蛋白 

分 类 号：R656.8[医药卫生—外科学]