枸地氯雷他定联合非索非那定治疗难治性荨麻疹患者的疗效  

Curative effect of desloratadine citrate disodium and fexofenadine in refractory urticaria

作　　者：付学锋[1] 王美燕[1] 张娜[1] 

机构地区：[1]金华市中心医院皮肤科

出　　处：《中国生化药物杂志》2017年第3期249-251,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 分析枸地氯雷他定联合非索非那定治疗难治性荨麻疹患者的临床疗效。方法 选取难治性荨麻疹患者作为观察对象,按照数字表法随机分为观察组与对照组,每组50例。对照组采用单药枸地氯雷他定片治疗,观察组在对照组的基础上加入非索非那定片治疗。比较2组患者的临床疗效、治疗前后免疫功能（CD3^＋、CD4^＋、CD4^＋/CD8^＋）变化,炎症因子[降钙素原（procalcitonin,PCT）、C反应蛋白（C-reactive protein,CRP）]指标变化以及生活质量变化,并记录2组患者治疗过程中的不良反应发生率。结果 观察组治疗总有效率为88.0%,显著高于对照组的72.0%（P〈0.05）。观察组治疗后各免疫功能观察指标均显著高于对照组（P〈0.05）。观察组治疗后各炎症因子指标水平均低于对照组（P〈0.05）。观察组睡眠质量合格率、运动质量合格率显著高于对照组（86.0%vs 68.0%,84.0%vs 66.0%,P〈0.05）。结论 枸地氯雷他定片联合非索非那定片在难治性荨麻疹的临床治疗中具有较好的应用效果,能够有效提高患者的免疫功能,降低炎症因子分泌,从而有效缓解患者的临床症状,改善其生活质量,且具有较高的安全性。Objective To analyze the clinical efficacy of desloratadine citrate disodium and fexofenadine in the treatment of refractory urticaria . Methods 100 patients with refractory urticaria were randomly divided into observation group and control group according to the digital table method, with 50 cases in each group.The control group were treated with desloratadine citrate disodium, and the observation group were treated with fexofenadine on the basis of control group.The efficacy, immunity function （ CD3^＋, CD4^＋, CD4^＋/CD8^＋） , the changes of inflammatory factors [ procalcitonin （ PCT） , C-reactive protein （ CRP） ] and the quality of life were compared between the two groups.The adverse reaction rate in two groups was recorded in two groups.Results The total efficacy in observation group （88.0%） was significantly higher than that in control group （72.0%）（P〈0.05）.The indicators of immunity function in observation group were significantly higher than those in control group（P〈0.05）.The inflammatory factors in observation group were significantly lower than those in control group （ P〈0.05 ） .The sleep and exercise quality rate of the observation group were significantly higher than those in control group（86.0% vs.68.0%,84.0% vs.66.0%,P〈0.05）.Conclusion The combination of desloratadine citrate disodium and fexofenadine in the treatment of refractory urticaria has a good effect, can effectively improve the immune function, reduce the secretion of inflammatory factors, thus effectively relieve the clinical symptoms, improve their quality of life, and has high security.

关 键 词：枸地氯雷他定片 非索非那定片 难治性荨麻疹 临床疗效 

分 类 号：R392.8[医药卫生—免疫学]