穿琥宁注射液对COPD合并CAP患者血浆IL-33、PCT及hs-CRP水平的影响  

Effects of potassium dehydroandrograpolide succinate injection on plasma IL-33, PCT and hs-CRP in COPD complicated with CAP

作　　者：张春玲 潘殿柱 孟晓皓[2] 

机构地区：[1]锦州医科大学附属一院呼吸科,辽宁锦州121000 [2]阜新市中心医院呼吸内科,辽宁阜新123000

出　　处：《中国生化药物杂志》2017年第3期279-281,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 探讨穿琥宁注射液对慢性阻塞性肺疾病（COPD）合并社区获得性肺炎（CAP）患者血浆白细胞介素-33（IL-33）、降钙素原（PCT）、超敏C反应蛋白（hs-CRP）水平的影响。方法 选取2015年4月～2016年8月本院收治的91例COPD合并CAP患者,随机分为观察组（48例）和对照组（43例）。对照组给予常规方案治疗,观察组则在上述基础上给予穿琥宁注射液进行治疗。治疗后对比2组患者的临床疗效及其血浆IL-33、PCT及hs-CRP水平。结果 治疗前,2组患者的IL-33、PCT以及hs-CRP等炎症介质水平差异无统计学意义。治疗后,观察组的总有效率为91.67%高于对照组的74.42%,差异有统计学意义（P〈0.05）;观察组的各临床症状缓解时间明显低于对照组,而其细菌清除率（85.42%）则明显高于对照组（67.44%）,差异有统计学意义（P〈0.05）;2组患者的各炎症介质水平均有所下降,观察组的各指标下降幅度明显大于对照组,差异有统计学意义（P〈0.05）。而观察组和对照组的不良反应发生率比较差异无统计学意义。结论 穿琥宁注射液能够显著改善其血浆IL-33、PCT及hs-CRP水平,使其呼吸道病原菌及炎性介质得到有效清除,具有较好的临床治疗效果,且在治疗期间未见严重不良反应发生。Objective To research the clinical evaluation of potassium dehydroandrograpolide succinate injection in the treatment of COPD combined with CAP and its influence on plasma IL-33, PCT and hs-CRP levels.Method 91 patients with COPD combined with CAP in our hospital from April 2015 to August 2016 were selected and divided into the observation group （48 cases） and the control group （43 cases）.The control group was given routine treatment, the observation group was given on the basis of the above treatment of potassium dehydroandrograpolide succinate injection.The clinical efficacy and plasma IL-33, PCT and hs-CRP levels were compared between the two groups after treatment.Results Before treatment, the IL-33, PCT, hs-CRP of two groups of patients had no significant difference.After treatment, the total effective rate of the observation group was 91.67% higher than that of the control group 74.42%, the difference was statistically significant （P〈0.05）.All the clinical symptoms time of the observation group was significantly lower than that of the control group, and the clearance rate of the observation group （85.42%） was significantly higher than that of the control group （67.44%）, the difference was statistically significant （P〈0.05）, the indexes of the two groups of patients were decreased, the indexes of the observation group significantly lower than that in control group, the difference was statistically significant （P〈0.05）.There was no significant difference in the incidence of adverse reactions between the observation group and the control group .Conclusion Potassium dehydroandrograpolide succinate injection can significantly improve their plasma IL-33, PCT and hs-CRP levels, the respiratory pathogen and inflammatory mediators are effectively removed, and has good clinical effect, and no serious adverse reactions during treatment.

关 键 词：穿琥宁注射液 慢性阻塞性肺疾病 社区获得性肺炎 白细胞介素-33 降钙素原 超敏C反应蛋白 

分 类 号：R563.9[医药卫生—呼吸系统]