基于胃肠动力障碍模型大鼠的气滞胃痛颗粒血清药物化学初步研究  

Preliminary study on serum pharmacochemistry of Qizhiweitong Particles based on gastrointestinal motility disorder in rats

作　　者：于晓萌[1] 王鹤臣 田露露[1] 孟宪生[1,2,3] 英锡相[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]辽宁省组分中药工程技术研究中心,辽宁大连116600 [3]辽宁省现代中药研究工程实验室,辽宁大连116600

出　　处：《药学研究》2017年第2期63-66,74,共5页Journal of Pharmaceutical Research

基　　金：国家自然科学基金(No.81241111);辽宁省高等学校优秀人才支持计划资助项目(No.LR2013044)

摘　　要：目的利用血清药物化学研究胃肠动力障碍模型大鼠灌胃气滞胃痛颗粒后的入血成分。方法采用超高效液相色谱-电喷雾-飞行时间质谱技术,确定胃肠动力障碍大鼠口服气滞胃痛颗粒提取物后血中移行成分及其代谢产物。结果胃肠动力障碍模型大鼠灌胃给予气滞胃痛颗粒后血清中检测25个移行成分,4个原型入血成分及21个代谢成分,并对其中的18个成分进行了结构推测。结论血中移行成分及代谢产物可能为气滞胃痛颗粒发挥促胃肠动力的体内直接作用物质,为明确气滞胃痛颗粒药效物质基础提供了科学依据。Objective To determine the absorbed constituents of compound Qizhiweitong Particles in gastrointestinal motility disorder rat blood by serum pharmacochemistry.Methods UPLC-ESI-Q-TOF/MS was used to establish the fingerprints of drug-containing serum of gastrointestinal motility disorder rats after intragastric administration of extract of Qizhiweitong Particles in order to preliminarily indentify the components absorbed into blood and metabolites of Qizhiweitong Particles in gastrointestinal motility disorder rats.Results Under above conditions,25 drug-induced constituents（ 4 prototype components,21 possible metabolites） were found in drug-containing serum.Conclusion The compounds absorbed into the blood are the effective constituents,and the research provides a scientific fundament for material basis of effectiveness of Qizhiweitong Particles.

关 键 词：气滞胃痛颗粒 血清药物化学 原型成分 代谢产物 

分 类 号：R975.1[医药卫生—药品]