超敏C反应蛋白检测在儿童细菌和支原体感染中的应用研究  

Application study of hsCRP detection in different types of child infections

作　　者：赵秋剑[1] 高海锋[1] 乔正梅[1] 颉璠 高炎超[2] 

机构地区：[1]陕西省宝鸡市中心医院检验科,721008 [2]南方医科大学附属何贤纪念医院检验科,广州510515

出　　处：《国际检验医学杂志》2017年第6期772-773,776,共3页International Journal of Laboratory Medicine

基　　金：广东省科学技术厅医药卫生基金资助项目(2012A030400049)

摘　　要：目的探讨超敏C反应蛋白(hsCRP)在儿童细菌性感染和支原体感染中的检测水平,以提高hsCRP检测的应用价值。方法选取2010年3月至2015年3月的101例感染患儿作为研究对象,根据血液学和细菌培养情况分成细菌感染组和支原体感染组,分别为67、34例。另外,选取同期健康的儿童体检者50例作为对照组。对上述幼儿抽取静脉血,分别检测hsCRP、白细胞(WBC)、中性粒细胞百分比(NEUT%)水平。结果细菌感染组hsCRP、WBC水平及异常率均高于支原体感染组和对照组(P<0.05);支原体感染组NEUT%及其异常率高于其他两组(P<0.05)。治疗后细菌感染组hsCRP、WBC水平和异常率均低于治疗前,差异均有统计学意义(P<0.05);hsCRP对细菌感染诊断的最大受试者工作特征曲线(ROC)曲线下面积为0.68,灵敏度、特异度分别为89.9%、88.3%。结论 hsCRP水平检测对儿童细菌感染有早期诊断价值,其检测可以动态地反映治疗效果。Objective To investigate the expression level of hyper sensitivity C-reactive protein（hsCRP）in children infected with different pathogens in order to enhance the application value of hsCRP.Methods One hundred and one children patients with infection from March 2010 to March 2015 were selected as the research subjects and divided into the bacterial infection group（67cases）and mycoplasma infection group（34cases）according to the hematology and bacterial culture results.Contemporaneous 50 healthy children were selected as the control group.Venous blood was collected for detecting hsCRP,white blood cell（WBC）and neutrophil percentage（NEUT%）.Results The levels and abnormal rates of hsCRP and WBC in the bacterial infection group were significantly higher than the those in the mycoplasma infection group and control group（P〈0.05）;NEUT%and abnormal rate in the mycoplasma infection group was higher than that in the other two groups（P〈0.05）.The levels and abnormal rates of hsCRP and WBC after treatment in the bacterial infection group were lower than those before treatment,the difference was statistically significant（P〈0.05）;the area under the ROC curve of hsCRP for diagnosing bacterial infection wa maximal,which was 0.68,the sensitivity and specificity were 89.9% and 88.3% respectively.Conclusion The hsCRP level detection has early diagnostic value for child bacterial infection and can dynamically reflects the curative effect.

关 键 词：超敏C反应蛋白 细菌感染 支原体感染 诊断 

分 类 号：R725.1[医药卫生—儿科] R446.5[医药卫生—临床医学]