哈乐递增双倍剂量联合肾舒颗粒治疗输尿管小结石59例体会  

Treatment of 59 Cases of Ureteral Calculus with Double Dose of Ha Le Increment Combined With Shenshu Granules

作　　者：王翌[1] 王锡智[1] 罗斐埜[1] 王博[1] 俞江[1] 季晋东[1] 顾擎[1] 

机构地区：[1]上海交通大学医学院附属苏州九龙医院泌尿外科,江苏苏州215021

出　　处：《哈尔滨医药》2017年第1期3-5,共3页Harbin Medical Journal

摘　　要：目的探讨盐酸坦索罗辛缓释胶囊(哈乐)递增双倍剂量联合肾舒颗粒治疗输尿管小结石的临床疗效。方法按照随机数字表的分组方法将163例输尿管下段结石患者分为三组:A组:59例,口服哈乐+肾舒颗粒,其中哈乐起始剂量0.2 mg qn,第3天开始加倍至0.4 mg qn,肾舒颗粒8 g tid。B组:53例,口服哈乐0.2 mg qn+肾舒颗粒8 g tid。C组,51例,口服哈乐0.2 mg qn。三组疗程均为10日。治疗后,统计比较三组治疗总有效率、肾绞痛发作率及体位性低血压发生率。结果治疗后,A组治疗有效率优于B组和C组,三组比较差异有统计学意义(P<0.05)。A组肾绞痛发作率低于B组和C组,三组比较差异有统计学意义(P<0.05);三组不良反应体位性低血压的发生率比较差异无统计学意义(P>0.05)。结论哈乐递增双倍剂量联合肾舒颗粒可提高输尿管小结石的临床治疗有效率,减少肾绞痛的发作率,且不良反应少,值得临床推广应用。Objective To investigate the effect of double dose of tamsulosin hydrochloride sustained release capsules（Ha Le）increment combined with Shenshu granules in the treatment of ureteral calculi.Methods According to the random number table methodm,163 cases of ureteral stones in the lower segment were divided into three groups：Group A：59 cases,Ha Le ＋ Shenshu granules oral administration,among which,ha Le starting dose was 0.2 mg qn,the third day doubled to 0.4 mg qn,Shenshu granules 8g tid.Group B：53 cases,Ha Le 0.2mg qn ＋ Shenshu granules 8g tid oral administration.Group C：51 cases,Ha Le 0.2 mg qn oral administration.After treatment of 10 days,the total effective rate,the incidence of renal colic,the number of stones and the incidence rate of adverse reaction were compared between the three groups.Results After treatment,the effective rate of A group was better than those of B group and C group,the difference was statistically significant（P〈0.05）.The renal colic attack rate in group A were lower than those in group B and group C,differences between the three groups have statistical significance（P〈0.05）.Adverse reactions of three groups of orthostatic hypotension incidence difference had no statistical significance（P〉0.05）.Conclusion The combination of double dose of HA Le and Shenshu granules can improve the clinical treatment of ureteral calculi,reduce the incidence of renal colic and adverse reactions,which is worthy of clinical application.

关 键 词：坦索罗辛 肾舒颗粒 输尿管小结石 疗效 

分 类 号：R453[医药卫生—治疗学]