非典型抗精神病药致体质量增加与神经肽Y基因关联性的研究  

Association Between Weight Gain Induced by Atypical Antipsychotic and Polymorphisms of NPY Gene

作　　者：张璇[1] 曾环思[1] 郭媛媛[1] 杨叶雅[1] 王知力[1] 

机构地区：[1]深圳市精神卫生中心药学部,广东深圳518020

出　　处：《中国医院用药评价与分析》2017年第2期173-175,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：2015年深圳市科技研发资金项目(No.JCYJ20150402093137766)

摘　　要：目的:探讨非典型抗精神病药致患者体质量增加与神经肽Y(neuropeptide Y,NPY)基因多态性的关系。方法:选取2015年10月—2016年4月深圳市精神卫生中心收治的精神分裂症患者124例作为研究对象,分为观察组和对照组,每组各62例。观察组为服用抗精神病药1年内体质量较服药前增加≥7%的患者,对照组为服用抗精神病药1年内体质量增加<7%的患者,2组患者治疗时间相差≤2个月。采用聚合酶链反应及基因测序技术,测定2组患者NPY基因启动子-399 T/C(rs16147)多态性。结果:2组患者NPY基因型及等位基因频率的差异均无统计学意义(P>0.05)。但TT基因型的患者经抗精神病药治疗后体质量增加的程度明显小于携带TC/CC基因型的患者,差异有统计学意义(t=-2.328,P<0.05)。结论:NPY基因启动子-399 T/C(rs16147)多态性对抗精神病药治疗后患者体质量增加程度有影响。OBJECTIVE ：To probe into the association between weight gain induced by atypical antipsychotic and the polymorphisms of neuropeptide Y （NPY gene ）. METHODS： 124 patients with schizophrenic admitted into Shenzhen Mental Health Center from Oct. 2015 to Apr. 2016 were selected to be divided into observation group and control group, with 62 cases in each. The observation group were ＇patients with weight gain more than 7% compared with their pre-drug body weight, and the control group were patients with weight gain less than 7%. The treatment time of two groups was ~〈 2 months. The polymorphism of - 399 T/C （rs16147） in the promoter of NPY gene was analyzed by using polymerase chain reaction and directly sequencing technology. RESULTS： There was no significant difference in the frequency of NPY genotypes and alleles between two groups （ P 〉 0. 05 ）. While after the treatment with atypical antipsychotic, the weight gain degree in patients with TT genotypes was less than patients with TC/CC genotypes （t = - 2. 328, P 〈 0.05 ）. CONCLUSIONS ： NPY gene promoter polymorphisms can affect the weight gain degree in patients with antipsychotic after treatment.

关 键 词：神经肽Y基因 非典型抗精神病药 体质量增加 基因多态性 

分 类 号：R971[医药卫生—药品]