西洛他唑与阿司匹林联合治疗腔隙性脑梗死的疗效观察  

Observation on Efficacy of Cilostazol Combined with Aspirin in Treatment of Lacunar Infarction

作　　者：代允义[1] 张秀萍[1] 孔羽[1] 张建平[1] 孟凡超[1] 

机构地区：[1]商丘市第一人民医院神经内科,河南商丘476100

出　　处：《中国医院用药评价与分析》2017年第2期212-213,217,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨西洛他唑与阿司匹林联合治疗腔隙性脑梗死的临床疗效及对脑部血流动力学的影响。方法:将56例腔隙性脑梗死患者以随机数字表法分为对照组和观察组,每组各28例。2组患者均进行常规对症治疗,在此基础上,对照组患者口服阿司匹林片(100 mg/d),观察组患者口服西洛他唑片(1次50 mg,1日2次)+阿司匹林(同对照组),2组均治疗12周。治疗前后,采用彩色多普勒超声仪检测平均流速(V_(mean))、阻力指数(resistance index,RI)、搏动指数(pulsatility index,PI)等脑部血流动力学指标;入院当日及治疗结束后根据美国国立卫生院卒中神经功能缺损评分量表对2组患者进行评分,参照评分变化情况评价临床疗效。结果:治疗前,2组患者V_(mean)、RI和PI水平的差异无统计学意义(P>0.05);治疗后,观察组患者的V_(mean)水平较治疗前明显升高、RI水平较治疗前明显降低,2组患者的PI水平均较治疗前明显降低,且观察组患者各项指标水平均明显优于对照组,差异均有统计学意义(P<0.05);观察组患者的总有效率为92.86%(26/28),明显高于对照组的64.29%(18/28),差异有统计学意义(P<0.05)。结论:西洛他唑与阿司匹林联合治疗腔隙性脑梗死,可以显著改善患者脑血流,治疗效果优于单用阿司匹林。OBJECTIVE：To probe into the efficacy of cilostazol combined with aspirin in treatment of lacunar infarction and the effects on cerebral haemodynamics. 56 patients lacunar infarction were extracted to be divided into observation group and control group via the random number table, with 28 cases in each. Two group of patients were given conventional treatment, based on which, the control group group were treated with oral Aspirin tablets（ 100 mg/d）, while the observation group received oral Cilostazol tablets（50 mg/time, 2 times/d） based on the control group. The treatment course was 12 weeks in two groups. Before and after treatment, the brain hemodynamic indexes about average velocity（ V ）, resistance index（RI） and pulsatility index（PI） were detected by color Doppler ultrasound. National institutes of health stroke scale（NIHSS） was adopted to score the patients in two groups on admission day and end of treatment. Clinical efficacy of two groups were evaluated according to the score changes. RESULTS： Before treatment, there was no statistically significant difference in two groups in V RI and PI （P 〉 0. 05 ）. After treatment, the level of V of observation group was significantly increased, yet RI was significantly decreased compared with before treatment, and the indicators in observation group were significantly higher than those of control group, with statistically significant difference （P 〈 0.05 ）. The total effective rate of observation group was 92. 86% （26/28）, significantly higher than that of control group [64. 29% （18/28）], with statistically significant difference （P 〈 0.05 ）. CONCLUSIONS： Cilostazol combined with aspirin in treatment of lacunar infarction can significantly improve patients＇ cerebral blood flow, with better clinical effects than single aspirin.

关 键 词：西洛他唑 腔隙性脑梗死 脑血流 

分 类 号：R971.1[医药卫生—药品] R973.2[医药卫生—药学]