冠状动脉介入治疗对冠心病患者血浆心肌肌钙蛋白T的影响  

Effect of coronary intervention therapy on serum cardiac troponin T in patients with

作　　者：周心涛[1] 赵黎丙[1] 闵新文[1] 陈娇[1] 郎明健[1] 

机构地区：[1]湖北医药学院附属东风医院心内科,湖北省十堰市442000

出　　处：《中国心血管病研究》2017年第2期135-137,共3页Chinese Journal of Cardiovascular Research

基　　金：2009年湖北省科技厅课题（项目编号：791）

摘　　要：目的探讨冠状动脉介入治疗对冠心病患者血浆心肌肌钙蛋白T（cTnT）的影响。方法随机抽取湖北医药学院附属东风医院2013年2月至2015年2月收治的90例冠心病患者为研究对象，其中45例经冠状动脉介入治疗患者为观察组，45例冠状动脉造影呈阳性但未经冠状动脉介入治疗的患者为对照组。两组患者平均年龄、性别比例、心肌梗死比例、不稳定型心绞痛比例、稳定型心绞痛比例、动脉堵塞≥70％比例等一般资料比较未见统计学差异（P〉0．05）。应用发光免疫法检测比较两组患者手术前后心肌cTnT水平变化并找出潜在影响因素。结果两组组内术前、术后比较：观察组cTnT术后显著上升，由0．04变为0．09，对照组无明显变化。两组组间比较：观察组术后cTnT值显著高于对照组，差异有统计学意义（P〈0．05）。经冠状动脉介入治疗患者中，cTnT升高组有胸痛情况3例，高于对照组0例，植入支架数目为2．13枚／例，高于对照组1．15枚／例，球囊扩张时间为（11．59±3．12）s，高于对照组（8．94±3．17）s，扩张压力为（14．13±1．92）kPa，高于对照组（12．04±2．16）kPa，分支血管闭塞为5例，高于对照组0例，与cTnT未上升组比较，差异有统计学意义（P〈0．05）。结论冠状动脉介入治疗对冠心病患者血浆cTnT存在一定影响。术后cTnT值上升，表明心肌出现一定程度损伤或血管内皮损伤。冠状动脉介入治疗能导致血浆cTnT的释放。Objective To investigate the effect of coronary intervention on myocardial troponin T in patients with coronary heart disease. Methods From February 2013 to February 2015, 90 patients with coronary heart disease （CHD） were randomly selected, and 45 patients with coronary intervention treatment were observed, and 45 patients with coronary artery angiography were positive but without coronary intervention treatment. The average age of the patients in both groups, the sex ratio, the proportion of myocardial infarction, unstable angina proportion, the proportion of stable angina, arterial blockage ratio≥70% and other general information was no statistically significant difference （P〉0.05）. Application of luminescent immunoassay, two groups of patients before and after surgery cardiac troponin T （cTnT） level changes and identify potential influencing factors. Results Two groups of patients before and after surgery, the observation group was significantly higher than the control group, the control group had no obvious change, the cTnT value of the two groups was significantly higher than that in the control group, the difference was statistieally significant （P〈0.05）. Pereutaneous coronary intervention in patients, elevated cTnT group chest pain in 3 cases, stent number was 2.13 higher than 1.15 cases in the control group, balloon time for （11.59±3.12）s higher than control group （8.94±3.17）s, expansion pressure for （14.13±1.92）kPa higher than control group （12.14±2.16）kPa, branching vascular occlusion in 5 eases higher than 0 cases in the control group. All the data above were higher than that of cTnT group, and the difference was statistically signifi-cant （P〈0.05）. Conclusion Coronary intervention treatment of coronary heart disease in patients with coronary heart disease, myocardial troponin T in the presence of a certain degree of influence, postoperative eTnT value increased, the myocardial injury or vascular endothelial, injury, coronary intervention can lead to the

关 键 词：冠状动脉介入治疗 冠状动脉疾病 心肌肌钙蛋白T 

分 类 号：R541.4[医药卫生—心血管疾病]