七氟烷联合丙泊酚对老年非小细胞肺癌胸腔镜切除术后认知功能及血清氧化应激水平的影响  

Effect of sevoflurane combined with propofol on postoperative cognitive function and serum oxidative stress level in elderly patients with non small cell lung cancer after thoracic surgery

作　　者：尤匡掌[1] 陈斌[1] 包倩倩[2] 

机构地区：[1]浙江省台州医院麻醉科 [2]浙江省台州医院手术室

出　　处：《中国临床药理学与治疗学》2017年第2期190-193,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：浙江省医药卫生科技计划项目(2011ZDA025)

摘　　要：目的:评价七氟烷联合丙泊酚对老年非小细胞肺癌(NSCLC)胸腔镜切除术后认知功能及血清氧化应激水平的影响。方法:116例老年NSCLC胸腔镜切除术患者随机分为对照组及试验组,各58例;对照组给予0.08 mg·kg^(-1)·min^(-1)丙泊酚靶控输注维持麻醉,试验组给予0.05 mg·kg^(-1)·min^(-1)丙泊酚靶控输注+0.8MAC七氟烷吸入以维持麻醉。比较两组患者血清神经特异性烯醇化酶(NSE)、β淀粉样蛋白(Aβ)、超氧阴离子自由基(O_2^-)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)水平、简易智能精神状态量表(MMSE)评分及安全性。结果:与对照组比较,试验组患者血清NSE、Aβ水平较低,MMSE评分较高(P<0.05)。试验组患者血清O_2^-、MDA水平较低,血清GSH-Px水平较高(P<0.05)。两组患者不良反应发生率无统计学差异(P>0.05)。结论:七氟烷联合丙泊酚能够降低老年NSCLC胸腔镜切除术后患者的血清氧化应激水平,减少对术后认知功能的影响,具有较高安全性。AIM：To evaluate the effect of sevoflurane combined with propofol on postoperative cognitive function and serum oxidative stress level in elderly patients with non small cell lung cancer （NSCLC） after thoracic surger.METHODS：116 cases of elderly patients with NSCLC after thoracic surger were randomly divided into the control group and treatment group,58 cases in each group.The control group was given target controlled infusion of 0.08 mg ＆#183; kg-1 ＆#183; min-1 propofol to maintain anesthesia,the experimental group was given target controlled infusion of 0.05 mg＆#183; kg1 ＆#183; min-1 propofol plus 0.8MAC sevoflurane for inhalation to maintain anesthesia.Serum neuro specific enolase （NSE）,amyloid protein β （Aβ）,Superoxide anion radical （O2-）,malondialdehyde （MDA）,glutathione peroxidase （GSH-Px） levels,mini mental state examination （MMSE） score and safety of the two groups were compared.RESULTS：Compared with the control group,serum levels of NSE、Aβ3 were lower and the MMSE score was higher in the experimental group （P 〈 0.05）.The serum levels of O2,MDA were lower and the serum level of GSH-Px was higher in the experimental group （P 〈 0.05）.There was no significant difference in the incidence of adverse reactions between the two groups （P 〉 0.05）.CONCLUSION：Sevoflurane combined with propofol can significantly decrease serum oxidative stress level in elderly patients with NSCLC after thoracic surgery and can reduce the impact on postoperative cognitive function while maintaing high safety.

关 键 词：七氟烷 丙泊酚 老年非小细胞肺癌 胸腔镜切除术 术后认知功能 氧化应激 

分 类 号：R614[医药卫生—麻醉学] R734[医药卫生—外科学]