β-七叶皂苷钠对重型颅脑损伤患者血清白介素-6与白介素-8的影响  

Effect of β-aescine Sodium on lnterleukin-6 and Interleukin-8 of Patients with Severe Traumatic Brain Injury

作　　者：贾翼鹏 杜江[2] 王勇[2] 

机构地区：[1]朝阳市中心医院神经外科,辽宁朝阳122000 [2]中国医科大学附属第一医院神经外科,沈阳110001

出　　处：《中国实用乡村医生杂志》2017年第3期64-65,68,共3页Chinese Practical Journal of Rural Doctor

摘　　要：目的探讨β-七叶皂苷钠对重型颅脑损伤患者血清白介素-6与白介素-8的影响。方法选取2014年11月-2015年10月在朝阳市中心医院神经外科就诊的50例脑出血重型脑损伤患者，随机分为观察组和对照组各25例。对照组给予神经外科常规治疗，观察组在常规治疗基础上给予β-七叶皂苷钠。治疗后采用ELISA法检测患者血清白介素-6与白介素-8水平，治疗3个月后进行格拉斯哥结局量表（GOS）评分。结果观察组血清白介素-6与白介素-8水平低于对照组，差异有统计学意义（P〈0．05）；观察组GOS评分高于对照组，差异有统计学意义（P〈0．05）。结论β-七叶皂苷钠能改善重型颅脑损伤患者的神经功能，其作用机制之一可能是降低白介素-6与白介素-8的表达。Objective To investigate the effect of β-aescine sodium on serum interleukin-6 and interleukin-8 of severe craniocerebral injury patients. Methods Fifty patients with severe brain injury admitted in Department of Neurosurgery in Central Hospital of Chaoyang City from November, 2014 to October, 2015 were selected and randomly divided into observation group and control group （n = 25）. The control group was given conventional treatment, while the observation group was given β-aescine sodium on the basis of routine treatment. Detection of serum interleukin-6 and interleukin-8 levels by ELISA method after treatment were carried out, and the scoring according to Glasgow Outcome Scale （GOS） was made three months after the treatment. Results The levels of serum interleukin-6 and interleukin-8 of the observation group was lower than those of the control group, and the differences were statistically significant （P 〈 0.05）. The GOS score of observation group was higher than that of the control group, and the difference was statistically significant （P 〈 0.05）. Conclusion β-aescine sodium can improve the neurological function of patients with severe craniocerebral injury, and one of the mechanisms may be the expression which reduces interleukin-6 and interleukin -8 expression.

关 键 词：重型颅脑损伤 Β-七叶皂苷钠 白介素-6 白介素-8 

分 类 号：R651[医药卫生—外科学]