经皮穴位电刺激对肺癌患者化疗后癌因性疲乏的效果观察  

Cancer-related fatigue in non-small cell lung cancer patients treated with transcutaneous electrical acupoint stimulation during periods of chemotherapy： an experimental pilot study

作　　者：吴奕帆 侯黎莉[1] 顾芬[2] 俞瑛[3] 

机构地区：[1]同济大学附属上海市肺科医院护理部,200433 [2]同济大学附属上海市肺科医院呼吸科,200433 [3]同济大学附属上海市肺科医院肿瘤科,200433

出　　处：《中国实用护理杂志》2017年第9期693-698,共6页Chinese Journal of Practical Nursing

基　　金：上海市人才发展资金资助（201449）

摘　　要：探讨经皮穴位电刺激对非小细胞肺癌患者化疗后癌因性疲乏的效果。方法共选取194例初次化疗的非小细胞肺癌患者按照随机数字表分成对照组66例、穴位组61例和假穴位组67例。对照组患者实施化疗常规护理；穴位组在常规护理基础上运用经皮穴位电刺激方法，分别取气海、膈腧和足三里穴；假穴位组则在常规护理基础上使用电刺激，避开上述穴位，且无其他穴位的区域。分别在初次化疗前1 d、第8天和第28天观察3组患者的Piper疲乏修订量表和癌症患者生命质量量表的评分指标。结果最终，167例患者参与并完成本研究，对照组56例，穴位组57例，假穴位组49例。化疗第28天，穴位组的Piper疲乏修订量表得分为（2.06 ± 0.90）分，假穴位组为（2.80 ± 1.34）分，对照组为（3.00 ± 1.29）分，3组比较差异有统计学意义（F=9.78，P〈0.01）；化疗第28天，穴位组的癌症患者生命质量量表得分为（64.56 ± 5.00）分，假穴位组为（54.90 ± 6.25）分，对照组为（54.48 ± 9.68）分，3组比较差异有统计学意义（F=34.12，P〈0.01）。结论长期使用经皮穴位电刺激对非小细胞肺癌患者化疗期间癌因性疲乏有缓解作用。ObjectiveTo explore the effectiveness of transcutaneous electrical acupoint stimulation （TEAS） approach in treating patients with cancer-related fatigue during periods of chemotherapy in non-small cell lung cancer （NSCLC） patients in China.MethodsA total of 162 participants who treated with GP chemotherapy were randomly assigned to three groups： 66 cases in control group, 61 cases in TEAS group, 67 cases in Sham TEAS group. The following acupoints were used in this study： Qihai （CV 6）, Keshu （UB 17）, and Zusanli （ST 36）. Participants in TEAS group and Sham TEAS group received eight 30-min sessions of TEAS over 28 days. The Revised Piper Fatigue Scale （RPFS） and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 （EORTC-QLQ-C30） were used to measure cancer related fatigue （CRF） on the day before chemotherapy days 8 and 28 separately. The differences among three groups were analyzed.ResultsFinally, 167 patients were included in this study, 56 cases in control group, 57 cases in TEAS group, 49 cases in Sham TEAS group. At the 28th day, the outcomes of the RPFS for TEAS group, Sham TEAS group and control groupscored 2.06 ± 0.90, 2.80 ± 1.34, 3.00 ± 1.29 respectively. There were significantly different among three groups （F=9.784, P〈0.01）. At the 28th day, the outcomes of the EORTC-QLQ-C30 for TEAS group, Sham TEAS group and control groupscored 64.56±5.00, 54.90±6.25, 54.48 ± 9.68 respectively. There were significantly different among three groups （F=34.119, P〈0.01）. ConclusionsTEAS could help to relived cancer-related fatigue.

关 键 词：肺肿瘤 癌因性疲乏 经皮穴位电刺激 实验性研究 

分 类 号：R473.73[医药卫生—护理学]