保护骨髓的容积旋转调强放疗对骨髓受照射剂量的影响  

Effect of volumetric modulated arc therapy with bone marrow protection on bone marrow irradiation in patients with cervical cancer after operation

作　　者：韦俊[1] 李齐林[1] 宁忠华[1] 顾文栋[1] 

机构地区：[1]常州市第一人民医院放射肿瘤科,江苏省213003

出　　处：《江苏医药》2017年第5期341-344,F0003,共5页Jiangsu Medical Journal

摘　　要：目的观察宫颈癌术后保护骨髓的容积旋转调强放疗(VMAT)对骨髓受照射剂量的影响。方法Ⅰ、Ⅱ期宫颈癌术后患者15例,均制定两套治疗计划,采用常规VMAT(A组)和限定骨髓剂量的VMAT(B组),比较两组骨髓受照射剂量差异。结果 B组骨髓受照剂量V_(10)和V_(20)均低于A组[(72.77±8.30)%vs.(86.27±8.80)%和(53.24±8.50)%vs.(70.24±7.80)%](P<0.05);但靶区覆盖度及膀胱V_(20)、V_(45)、直肠V_(45)、小肠V_(15))、V_(40)骨髓受照剂量差异不明显(P>0.05)。结论限定骨髓剂量VMAT可部分减少靶区骨髓受照剂量。Objective To observe the effect of volumetric modulated arc therapy（VMAT）with bone marrow protection on bone marrow irradiation in the patients with cervical cancer after operation.Methods Fifteen patients with stage Ⅰ-Ⅱ cervical cancer were treated with two therapeutic regimes of conventional VMAT（group A）and dose-limited bone marrow irradiation VMAT（group B）,respectively.The dosimetric differences of bone marrow irradiation were compared between two groups.Results The doses of bone marrow irradiation V_（10） and V_（20） were lower in group B than those in group A[（72.77±8.30）% vs.（86.27±8.80）% and（53.24±8.50）% vs.（70.24±7.80）%]（P〈0.05）.There were no significant differences in the target coverage and the doses of irradiation for the bladder V_（20）,V_（45）,the rectum V_（45） and the small bowel V_（15） and V_（40） （P〈0.05）.Conclusion The dosage of bone marrow irradiation can be reduced in a certain degree by VMAT with bone marrow protection in the cervical cancer patients undergoing postoperative radiotherapy.

关 键 词：宫颈癌 容积旋转调强放疗 骨髓保护 

分 类 号：R815[医药卫生—放射医学]