早产儿坏死性小肠结肠炎危险因素临床分析  

Clinical Analysis of Risk Factors for Premature Infant Necrotizing Enterocolitis in Premature Infants

作　　者：孙海祥[1] 高荣荣[2] 郑家峰 孙璐双 刘伟[1] 王晓静[1] 钟艳青 张立明[3] 

机构地区：[1]潍坊医学院儿科学教研室,山东潍坊261053 [2]济宁市第一人民医院新生儿科 [3]潍坊市人民医院新生儿科

出　　处：《潍坊医学院学报》2017年第1期60-62,共3页Acta Academiae Medicinae Weifang

摘　　要：目的探讨早产儿坏死性小肠结肠炎(NEC)临床上的危险因素。方法收集2013年12月~2016年9月期间在潍坊市人民医院新生儿科新生儿重症监护病房的37例临床资料完整的早产儿NEC患儿作为观察组,同时期收治的60例临床资料完整的非NEC的早产患儿作为对照组,两组患儿的一般资料相近,应用Logistic回归分析方法,对影响早产儿NEC临床常见病因,包括严重感染、生后窒息、妊娠期高血压综合征、发病前输血、母乳喂养、补充益生菌、新生儿低血糖及新生儿呼吸窘迫综合征(NRDS)进行回顾性分析。结果新生儿低血糖、NRDS等因素之间差异无统计学意义(P>0.05),严重感染、生后窒息、妊娠期高血压综合征、发病前输血、母乳喂养及补充益生菌等因素比较,差异有显著的统计学意义(P<0.05)。结论严重感染、生后窒息、妊娠期高血压综合征、发病前输血是主要危险因素,母乳喂养级补充益生菌是早产儿NEC的保护性因素。Objective To investigate the risk factors in premature infants with necrotizing enterocolitis clini- cal. Methods A clinical data of 37 cases premature infants were collected from December 2013 to September 2016 ad- mitted to neonatal intensive care unit of weifang people＇s hospital,60 cases of them were not preterm infant as the con- trol, the two groups were almost same. the Logistic regression analysis of the factors were did, including serious infections, birth asphyxia, pregnancy-induced hypertension, before the onset of blood transfusion, breastfeeding, add probiotics, neo- natal hypoglycemia and neonate respiratory distress syndrome. Results There was no significant difference of neonatal hypoglycemia and neonate respiratory distress syndrome （ P 〉 0.05） , the rest factors including serious infections, birth as- phyxia, pregnancy-induced hypertension, before the onset of blood transfusion had a significant difference between the two groups （P 〈 0.05）. Conclusions Serious infections, birth asphyxia and gestational hypertension are the major risk fac- tors for premature infants NEC,probiotic supplement is a protective factor of NEC in preterm infants.

关 键 词：早产儿 坏死性小肠结肠炎 危险因素 LOGISTIC回归分析 

分 类 号：R722.6[医药卫生—儿科]