重型脑室出血外引流注入尿激酶后保留时间的探讨  

Exploration on retention time of urokinase after performing lateral ventricle drainage in the ;treatment of severe ventricular hemorrhage

作　　者：郭金光[1] 李海燕[2] 王竞[3] 许建强[1] 李玉生[1] 孙立[1] 

机构地区：[1]冀中能源峰峰集团总医院神经外科,河北邯郸056200 [2]冀中能源峰峰集团总医院骨五科,河北邯郸056200 [3]冀中能源峰峰集团总医院泌尿外科,河北邯郸056200

出　　处：《中国医师进修杂志》2017年第2期142-144,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的：探讨尿激酶侧脑室灌注治疗重型脑室出血时保留时间对血肿消散的影响。方法回顾分析62例行双侧脑室穿刺外引流的重型脑室出血患者的临床资料，按尿激酶保留时间长短分为三组，A组（20例）保留1 h，B组（22例）保留2 h，C组（20例）保留3 h，观察比较三组患者在不同时间段血肿消散情况。结果术后第5～6、7～9、10～12天，A组血肿消散分别为2、5、13例，B组为5、13、4例，C组为3、13、4例，三组血肿消散时间比较差异有统计学意义（P=0.008）。两两比较结果显示：A组与B组比较差异有统计学意义（P=0.005），A组与C组比较差异有统计学意义（P=0.012），B组与C组比较差异无统计学意义（P=0.621）。三组并发症发生率比较差异无统计学意义（χ2=2.540，P=0.281）。结论尿激酶脑室内保留2 h对重型脑室出血外引流是比较合适的。Objective To evaluate the effect of retention time of urokinase on hematoma dissipation in the treatment of severe ventricular hemorrhage by lateral ventricle drainage. Methods The clinical data of 62 patients with severe ventricular hemorrhage and having received bilateral ventriculostomy were retrospectively analyzed. These patients was divided into 3 groups according to the retention time of urokinase： A group （20 patients, retention time 1 h）, B group （22 patients, retention time 2 h） , and C group （20 patients , retention time 3 h）.The number of patients with complete hematoma dissipation at different time in each group were compared. Results At 5-6 d, 7-9 d and 10-12 d after operation, the number of hematoma dissipation in A group was 2, 5, 13 cases, in B group was 5, 13, 4 cases, and in C g group was 3, 13, 4 cases. The number of hematoma dissipation patients in three groups had significant difference （P=0.008）, the number of hematoma dissipation patients between A group and B group, and between A group and C group had significant differences （P=0.005, 0.012）, but there was no significant difference between B group and C group （P=0.621）. The complication rate in three groups had no significant difference （χ2=2.540, P=0.281）. Conclusions The 2 h retention time of urokinase is more suitable for the patients with severe ventricular hemorrhage who underwent external drainage.

关 键 词：时间 血肿消散 重型脑室出血 尿激酶 

分 类 号：R651.1[医药卫生—外科学]