促甲状腺激素受体抗体的检测及其在Graves病诊疗中的价值  

Thyroid stimulating hormone receptor antibodies assays and its clinical significance in Graves＆#39; disease

作　　者：韩煦[1] 魏军平[1] Han Xu Wei Junping(Department of Endocrinoloty, Guang＇ anmen Hospital, Academy of Chinese Medical Sciences, Beifing 100053, China)

机构地区：[1]中国中医科学院广安门医院内分泌科,北京100053

出　　处：《国际内分泌代谢杂志》2017年第2期94-97,共4页International Journal of Endocrinology and Metabolism

基　　金：基金项目：首都卫生发展科研专项基金资助项目（2014-2-4152）;中央保健科研课题（w2013BJ45）;国家自然科学基金资助项目（81573961）

摘　　要：血清促甲状腺激素受体抗体（TRAb）是Graves病的特征性抗体,伴随生物检验技术的进步,TSAb的检测方法历经了三代发展.目前的多数研究证实,检测TRAb不仅有助于判断甲状腺毒症发生的原因、评估甲状腺功能、制定诊疗方案,同时对Graves病的相关疾病如Graves眼病、胫前黏液性水肿、肝功能损害病情的评估有重要意义,通过监测TRAb可以一定程度上控制Graves病及其并发症的加重或者复发.检测有Graves病病史的孕妇血清TRAb对安全妊娠也有意义.将目前TRAb的检测方法及其临床意义的研究进展作一综述,有助于临床医师通过TRAb做出决策并提高临床疗效.Serum thyroid stimulating hormone （TSH） receptor antibodies （TRAb） are considered to be characteristic antibodies of Graves＇ disease.As the development of immunology examination technology,TRAb assays underwent three generations.Many studies confirmed that TRAb was helpful to determine the cause of thyrotoxicosis,evaluate the function of thyroid and formulate diagnosis and treatment regimen.It is also significant in the evalation of Graves＇ disease related diseases,such as Graves＇ ophthalmopathy,pretibial myxoedema and liver damage of the diseases.Monitoring of TRAb would control the development or recurrence.Testing the TRAb of pregnant women with the history of Graves＇ disease is meaningful for safety of pregnancy.Rewiewing TRAb assays and clinical significance in Graves＇ disease is useful to clinicist in making clinical decision and improving the curative effect.

关 键 词：促甲状腺激素受体抗体 甲状腺功能亢进症 GRAVES眼病 

分 类 号：R581.1[医药卫生—内分泌]