肿瘤相关性低磷骨软化症的诊疗进展  

Diagnosis and treatment of tumor induced osteomalacia

作　　者：邵怡[1] 王安平[1] 王先令[1] 母义明[1] Shao Yi Wang Anping Wang Xianling Mu Yiming(Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China)

机构地区：[1]解放军总医院内分泌科,北京100853

出　　处：《国际内分泌代谢杂志》2017年第2期112-115,共4页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81471026）

摘　　要：肿瘤相关性低磷骨软化症是一种由于肿瘤分泌过多的利磷因子,如成纤维细胞生长因子-23（FGF-23）等,引起肾脏排磷增多造成的获得性代谢性骨病.肿瘤多来源于间叶组织,位于骨或软组织内,位置隐匿.临床表现为随病程进展逐渐加重的骨骼疼痛、活动受限、肌无力等.骨X线摄片可见骨密度普遍降低,骨小梁影模糊.本病为一种少见病,临床表现复杂多变,患者就诊科室分散,因此误诊、误治率高.但是通过积极的定性和定位检查,明确定位肿瘤,手术全切后可以痊愈.Tumor induced osteomalacia （TIO） is an acquired metabolic bone disease caused by tumors secreting high concentration of phosphatonins such as fibroblast growth factor-23 （FGF-23）,resulting in renal phosphate wasting.The tumors are derived from mesenchymal tissue in bone or soft tissues,and always located in obscure tissues.Clinical manifestations include progression of bone pain,activity limitation,muscle weakness,etc.Bone X-ray films show lower bone mineral density and fuzzy bone trabecular.Patients with TIO always look for medical care in various departments because of these complex manifestations.As a result,the rates of misdiagnosis and mistreatment are high previously.With multiple qualitative and positioning inspection,this disease can be clearly diagnosed and cured after tumor complete resection.

关 键 词：肿瘤相关性低磷骨软化症 代谢性骨病 病理性骨折 间叶组织肿瘤 生长抑素 

分 类 号：R68[医药卫生—骨科学] R730.5[医药卫生—外科学]