microRNA与脂肪组织慢性低度炎性反应  

microRNA and chronic low-grade inflammation of adipose tissue

作　　者：高晶扬 张曼娜[1] 曲伸[1] Gao Jingyang Zhang Manna Qu Shen(Department of Endocrinology, The Tenth People＇s Hospital of Shanghai, Tongji University, Shanghai 200072, Chin)

机构地区：[1]同济大学附属第十人民医院内分泌科,上海200072

出　　处：《国际内分泌代谢杂志》2017年第2期135-138,共4页International Journal of Endocrinology and Metabolism

摘　　要：脂肪组织慢性低度炎性反应是肥胖、2型糖尿病、高血压、心血管疾病等代谢性疾病的中心环节.研究脂肪组织慢性低度炎性反应的精确调控过程,对于预防和治疗肥胖及相关疾病有重要意义.microRNA是一类非编码RNA,具有调节基因表达的功能.研究显示,microRNA对脂肪组织巨噬细胞、经典炎性反应信号通路及炎性因子、抗炎因子等具有调控作用.Chronic low-grade inflammation in adipose tissue is the central link of obesity,type 2 diabetes,hypertension,cardiovascular disease and other metabolic diseases.It is important to study the regulation of chronic low-grade inflammation in adipose tissue,which will help us to prevent and treat obesity and related diseases.MicroRNA is a class of small non-coding RNA,and is responsible for the regulation of gene expression.Studies show that miRNA could regulate macrophage,classical inflammatory signaling pathway and inflammatory factors and anti-inflammatory factors.

关 键 词：慢性低度炎症 MICRORNA 脂肪组织 炎症因子 

分 类 号：R58[医药卫生—内分泌]