人咬肌内注射A型肉毒毒素后组织形态学观察  

Histomorphologic changes of masseter muscle after botulinum toxin A injection

作　　者：朱顺文[1] 王君[1] 马昊[2] 徐国栋[2] 马福顺[1] 

机构地区：[1]潍坊医学院,山东潍坊261042 [2]潍坊市人民医院病理科,山东潍坊261042

出　　处：《中国美容整形外科杂志》2017年第3期141-144,共4页Chinese Journal of Aesthetic and Plastic Surgery

摘　　要：目的观察人咬肌内注射A型肉毒毒素后咬肌纤维的组织形态学改变。方法自2011年4月至2015年10月,收集60例双侧下颌骨肥大伴咬肌肥大患者的左侧和右侧咬肌标本,共120份。将60份未注射A型肉毒毒素的咬肌标本作为对照组,60份已注射A型肉毒毒素的咬肌标本作为实验组。两组标本均行石蜡切片和HE染色,光镜下观察两组咬肌纤维的基本结构,测量其横截而面积,并进行统计学分析。结果光学显微镜观察,未发现两组咬肌纤维的基本结构发生改变,两组咬肌纤维横截面而积的差异具有统计学意义(P<0.05)。咬肌纤维横截面面积在第12周时减小程度最大,之后减小趋势放缓,第24周时,与第12周时的面积基本一致。结论 A型肉毒毒素能诱导人咬肌萎缩,在注射后第12周时萎缩程度最大,之后无明显变化。Objective The histomorphologic changes of masseter muscle after botulinum toxin A injection were observed.Methods From April 2011 to October 2015,60 patients with bilateral mandibular and masseter hypertrophy were involved in this study.There were a total of 120 masseter muscle specimens.Among them,60 specimens without botulinum toxin A injection were selected as the control group,and the other 60 specimens,with botulinum toxin A injection,as the experimental group.Paraffin section and HE staining were performed in both two groups.Basic structure of the masseter muscle fiber was observed under light microscope and the cross-sectional area was measured.The data above were analyzed statistically.Results No change of the basic structure of the masseter muscle fiber was found between the two groups.Compared to the control group,the cross-section area of the masseter muscle fiber decreased more significantly （P〈0.05）.The cross-section area of the masseter muscle fiber reached a minimum at the 12th week and gradually recovered after that.No further changes were noticed after another 12-week interval.Conclusion Masseter muscle atrophied after Botulinum toxin A injection.The masseter muscle reached a minimum at the 12th week,and no obvious change occurred after that.

关 键 词：A型肉毒毒素 咬肌肌纤维 咬肌肥大 肌纤维横截面面积 

分 类 号：R622[医药卫生—整形外科] R782.2[医药卫生—外科学]