益气活血方治疗冠心病气虚血瘀证作用机制研究进展  

Mechanism of Yiqi Huoxue Decoction in Treating Coronary Heart Disease with Qi Deficiency and Blood Stasis Syndrome

作　　者：赵爱梅[1,2] 任钧国[1] 刘建勋[1] 

机构地区：[1]中国中医科学院西苑医院,基础医学研究所,中药药理北京市重点实验室,北京100091 [2]北京中医药大学研究生院,北京100029

出　　处：《中国实验方剂学杂志》2017年第7期215-220,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点基础研究发展计划(973计划)项目(2015CB554405)

摘　　要：气虚血瘀证是冠心病临床常见证型,治疗多以益气活血化瘀为基本法则,补阳还五汤、八珍汤、芪参益气滴丸等益气活血方是治疗冠心病气虚血瘀证常用方,并有较好的临床疗效。益气活血方对冠心病的治疗具有多层面、多靶点、多环节的优势,且临床组方用药灵活,副作用小。目前对冠心病气虚血瘀证治疗的相关文献研究已较多,但主要聚焦在治疗方法、疗效观察及方药总结几个方面,缺少对方药作用机制的深入研究及归纳总结。为了明确益气活血方作用的靶向性,本文对近10年国内外相关文献进行整理,得出益气活血方治疗冠心病气虚血瘀证的作用机制主要包括以下几点:改善心功能、抗血小板聚集、改善血液流变学、保护血管内皮、减轻炎证反应、调脂稳定斑块、减轻氧化应激、增加冠状动脉血流量等。明确中药的作用靶标,不仅有益于指导临床用药,也有助于推动中医药事业的发展。本文对益气活血方治疗冠心病气虚血瘀证作用机制进行了系统的综述,从中医病证结合与方证对应的特点出发,借助现代药理研究,来阐明益气活血方的作用机制,这将为冠心病气虚血瘀证的治疗及益气活血方机制的深入研究提供一定的参考。加强中药方剂作用机制的研究,可能是未来研究益气活血药治疗冠心病气虚血瘀证的一个重要方向。The syndrome of Qi deficiency and blood stasis is a common syndrome of coronary heart disease in clinic. The basic treatment principle is to supplement Qi and activate blood circulation. Qi supplementing and blood circulation activating recipes, like Buyang Huanwutang, Bazhentang, Qishen Yiqi pills, are commonly used in clinic, with a good clinical curative effect. Yiqi Huoxue decoction has multiple-level, multiple-target and multiple-link advantages in treating coronary heart disease, with flexible clinical composition and small side effect. Current literature researches about treating coronary heart disease with Qi deficiency and blood stasis mainly focus on summarization of therapeutic methods, curative effect observation and prescriptions, without in-depth research and summarization of mechanisms of prescriptions. In order to clarify the targets of Yiqi Huoxue decoction, we collected relevant domestic and foreign literatures in ten years, and summarized mechanisms of Yiqi Huoxue decoction in treating coronary heart disease with Qi deficiency and blood stasis syndrome as follows： improving heart function, resisting platelet aggregation, improving blood theology, protecting vascular endothelium, reducing inflammatory reaction, regulating blood lipid and stablizing plaque, reducing oxidative stress, increasing blood flow of coronary artery. The definition of targets of traditional Chinese medicine （TCM） is not only beneficial to guide clinical medicine, but also useful to advance the development of TCM. This paper is a systematic review of Yiqi Huoxue decoction＇s mechanism in treating coronary heart disease with Qi deficiency and blood stasis syndrome, and combined the characteristics of TCM with the modern pharmacological researches to elucidate the mechanism of Yiqi Huoxue decoction. This will provide some references for further studies for therapies for coronary heart disease and their mechanisms. Strengthening of researches on the mechanism of TCM prescriptions may be an important direction for futur

关 键 词：冠心病 气虚血瘀证 益气活血方 作用机制 

分 类 号：R287[医药卫生—中药学]