宫颈癌与女性生殖道感染的相关性研究  

Correlation between cervical cancer and female genital tract infection

作　　者：陈丹[1] 金卓杏[1] 张晓兰[1] 兰彩娇[1] 朱晓华[1] 

机构地区：[1]丽水市中心医院妇产科,浙江丽水323000

出　　处：《中华医院感染学杂志》2017年第6期1374-1376,1383,共4页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生一般研究计划基金资助项目(2015KYB406)

摘　　要：目的观察宫颈癌与女性生殖道人乳头瘤病毒、单纯疱疹病毒Ⅱ型、沙眼衣原体、滴虫、细菌性阴道病感染的相关性。方法选择医院2012年1月-2015年12月宫颈癌患者100例为宫颈癌组,健康体检女性100名为对照组,检测生殖道人乳头瘤病毒、单纯疱疹病毒Ⅱ型、沙眼衣原体、滴虫、细菌性阴道病感染情况。结果宫颈癌组患者生殖道人乳头瘤病毒、单纯疱疹病毒Ⅱ型、沙眼衣原体、滴虫、细菌性阴道病的感染率均高于对照组,差异有统计学意义(P<0.05);宫颈癌组高危型人乳头瘤病毒检出率明显高于对照组,差异有统计学意义(P<0.05);宫颈癌组人乳头瘤病毒合并沙眼衣原体、人乳头瘤病毒合并滴虫、人乳头瘤病毒合并细菌性阴道病的感染率均高于对照组,差异有统计学意义(P<0.05);高危型人乳头瘤病毒感染和沙眼衣原体、滴虫、细菌性阴道病感染均呈正相关,差异有统计学意义(P<0.05)。结论宫颈癌的发生与生殖道感染有关,宫颈癌患者生殖道人乳头瘤病毒感染以高危型为主,高危型人乳头瘤病毒感染和沙眼衣原体、滴虫、细菌性阴道病感染均呈正相关。OBJECTIVE To observe the correlation between the cervical cancer and the female genital tract human papillomavirus,herpes simplex virus typeⅡ,Chlamydia trachomatis,Trichomonas or bacterial vaginosis infection.METHODS Totally 100 patients with cervical cancer who were treated in the hospital from Jan 2012 to Dec2015were chosen as the cervical cancer group,and 100 healthy women who received physical examination were set as the control group.The prevalence of genital tract human papillomavirus,herpes simplex virus typeⅡ,C.trachomatis,trichomonas or bacterial vaginosis infection was detected.RESULTS The incidence rate of the genital tract human papillomavirus,herpes simplex virus typeⅡ,C.trachomatis,trichomonas or bacterial vaginosis infection was higher in the cervical cancer group than in the control group（P〈0.05）.The detection rate of highrisk human papillomavirus of the cervical cancer group was significantly higher than that of the control group,and there was significant difference（P〈0.05）.The incidence rate of human papillomavirus mixed with C.trachomatis,human papillomavirus mixed with trichomonas,or human papillomavirus mixed with bacterial vaginosis infection was significantly higher in the cervical cancer group than in the control group（P〈0.05）.The high-risk human papillomavirus infection was positively correlated with the C.trachomatis,Trichomonas and bacterial vaginosis infection,and there was significant difference（P〈0.05）.CONCLUSIONThe incidence of cervical cancer is associated with the genital tract infection.The patients with high-risk human papillomavirus infection are dominant among the cervical cancer patients with genital tract infection.The high-risk human papillomavirus infection is positively correlated with the C.trachomatis,Trichomonas or bacterial vaginosis infection.

关 键 词：宫颈癌 人乳头瘤病毒 单纯疱疹病毒 沙眼衣原体 滴虫 细菌性阴道病 

分 类 号：R711[医药卫生—妇产科学]