梅毒孕妇抗梅毒治疗时机对新生儿梅毒感染的影响研究  

Influence on anti-syphilis treatment timing for pregnant women with syphilis on syphilis infection in neonates

作　　者：徐美凤 魏青 何婷 朱杰 骆文龙 陈静[2] 

机构地区：[1]杭州市富阳区妇幼保健院妇女保健科,浙江杭州311400 [2]广西医科大学第四附属医院超声科,广西柳州545005

出　　处：《中华医院感染学杂志》2017年第6期1387-1390,共4页Chinese Journal of Nosocomiology

基　　金：广西壮族自治区卫生厅基金资助项目(Z2013615)

摘　　要：目的探讨梅毒孕妇抗梅毒治疗时机对新生儿梅毒感染的影响,为先天性梅毒预防治疗提供参考。方法选取2014年1月-2015年6月诊治的妊娠期梅毒孕妇100例,根据治疗时机分为早期组(孕周≤20周,63例)与晚期组(孕周>20周,37例),均给予苄星青霉素治疗,观察妊娠结局、新生儿预后。结果早期组2例流产、2例早产,早期组预后不良率为6.35%、足月分娩率为93.65%,晚期组流产2例、早产7例,晚期组预后不良率为24.32%、足月分娩率为85.68%,比较差异有统计学意义(P<0.05);早期组分娩新生儿发生新生儿窒息4例、低体重4例、梅毒感染2例,发生率分别为6.35%、6.35%、3.17%,晚期组分娩新生儿发生新生儿窒息8例、低体重9例、梅毒感染8例,发生率分别为21.62%、24.32%、21.62%,比较差异有统计学意义(P<0.05);早期组RPR滴度<1:8、≥1:8的孕妇分娩新生儿分别有0例、2例为梅毒感染,梅毒感染率为0、3.17%,早期组RPR滴度<1:8、≥1:8的孕妇分娩新生儿分别有1例、7例为梅毒感染,梅毒感染率为2.70%、18.92%,两组RPR滴度<1:8孕妇分娩新生儿梅毒感染率比较差异无统计学意义,RPR滴度≥1:8孕妇分娩新生儿梅毒感染率比较差异有统计学意义(P<0.05)。结论梅毒孕妇抗梅毒治疗时机越早新生儿梅毒感染率越低,妊娠结局及新生儿预后越好。OBJECTIVE To explore the influence of anti-syphilis treatment timing for pregnant women with syphilis on syphilis infection in neonates so as to provide guidance for prevention and treatment of congenital syphilis.METHODS A total of 100 pregnant women with gestational syphilis who were treated from Jan 2014 to Jun 2015 were enrolled in the study and divided into the early stage group（no more than 20 weeks of gestation,63cases）and the late stage group（more than 20 weeks of gestation,37cases）according to the treatment timing,all of the enrolled pregnant women were treated with benzathine penicillin,and the pregnancy outcomes and prognosis of neonates were observed.RESULTS There were 2cases of abortion and 2cases of premature delivery in the early stage group;there were 2cases of abortion and 7cases of premature delivery in the late stage group;the rate of poor prognosis was 6.35%in the early stage group,24.32%in the late stage group;the rate of full-term delivery was93.65%in the early stage group,85.68% in the late stage group,and there was significant difference（P〈0.05）.There were 4（6.35%）neonates with neonatal asphyxia,4（6.35%）cases of low birth weight,and 2（3.17%）cases of syphilis infection in the early stage group,and there were 8（21.62%）neonates with neonatal asphyxia,9（24.32%）cases of low birth weight,and 8（21.62%）cases of syphilis infection in the late stage group（P〈0.05）.There was no neonate with syphilis infection who was given birth by the pregnant women with RPR titer less than 1：8and 2（3.17%）neonates with syphilis infection who were given birth by the pregnant women with the RPR titer no less than 1：8in the early stage group;there was 1（2.70%）neonate with syphilis infection who was given birth by the pregnant women with RPR titer less than 1：8and 7（18.92%）neonates with syphilis infection who were given birth by the pregnant women with the RPR titer no less than 1：8in the early stage group;there was no significant difference in the incidence

关 键 词：妊娠期梅毒 先天性梅毒 抗梅毒 治疗时机 

分 类 号：R514[医药卫生—内科学]