不同剂量头孢哌酮舒巴坦治疗单纯性淋病的临床对比研究  

Comparative study of different doses of cefoperazone sulbactam in the treatment of uncomplicated gonorrhea

作　　者：许慧芳 杜秋燕 刘样满 陈俊杰 王润龙 

机构地区：[1]平顶山市第二人民医院皮肤性病科,河南平顶山467000

出　　处：《中国性科学》2017年第3期61-64,共4页Chinese Journal of Human Sexuality

摘　　要：目的:探讨不同剂量头孢哌酮舒巴坦治疗单纯性淋病疗效,以期提高临床诊治水平。方法:选取2011年12月至2013年12月88例单纯性淋病患者为研究对象,分成两组。对照组44例,予1.5g头孢哌酮舒巴坦治疗;观察组44例,予2.25g头孢哌酮舒巴坦治疗。观察治疗后在1d、4d、7d疗效比较,观察临床症状体征和实验室检查恢复情况。结果:治疗1d,对照组显效率4.55%、总有效率34.09%,观察组显效率18.19%、总有效率54.55%,观察组在显效率和总有效率上显著高于对照组(P<0.05);治疗4d,对照组痊愈率13.65%、总有效率54.44%,观察组痊愈率29.54%、总有效率77.27%,观察组在痊愈率和总有效率上显著高于对照组(P<0.05);治疗7d后两组在痊愈率和总有效率上比较差异无统计学意义(P>0.05);在不良反应上比较差异无统计学意义(P>0.05);对照组尿频、尿痛发生率分别为47.73%、45.45%,脓性分泌物、龟头(外阴)红肿发生率分别为56.82%、43.18%,淋球菌涂片、淋球菌培养、氧化酶试验阳性率分别为65.91%、70.45%、75.00%;观察组尿频、尿痛发生率分别为34.09%、25.00%,脓性分泌物、龟头(外阴)红肿发生率分别为31.82%、22.73%,淋球菌涂片、淋球菌培养、氧化酶试验阳性率分别为27.27%、45.45%、50.00%,观察组明显优于对照组,两组比较差异显著(P<0.05)。结论:2.25g头孢哌酮舒巴坦治疗单纯性淋病疗效确切,不良反应低。Objectives： To study the effect of different doses of cefoperazone sulbactam in the treatment ofuncomplicated gonorrhea. Methods： 88 patients with simple gonorrhea from December 2011 to December 2013 were selected and divided into two groups,control group and observation group,with 44 cases in each group. Control group received 1. 5g of cefoperazone sulbactam treatment,and observation group received 2. 25 g of cefoperazone sulbactam treatment. Efficacy on the 1st,4th,7thday after treatment was compared. Clinical symptoms and laboratory recovery were observed. Results： On the 1stday after treatment,the significant efficiency of control group was4. 55% and the total efficiency was 34. 09%. The significant efficiency of observation group was 18. 19% and the total efficiency was 54. 55%. The differences was significant（ P〈0. 05）. On the 4thday after treatment,the cure rate of control group was 13. 65% and the total efficiency was 54. 44%. The cure rate of observation group was29. 54% and the total efficiency was 77. 27%. The differences was significant（ P〈0. 05）. On the 7thday after treatment,there was no significant difference between two groups in cure rate and total efficiency（ P〉0. 05）,so as the difference in adverse reactions between the two groups（ P〉0. 05）. In control group,urinary frequency and dysuria occurred rates were 47. 73% and 45. 45%,purulent discharge and glans（ genital） swollen rates were56. 82% and 43. 18%,positive rates of Neisseria gonococcus smear,Neisseria gonococcus culture and oxidase test were 65. 91%,70. 45% and 75%,respectively. In observation group,urinary frequency and dysuria occurred rates were 34. 09% and 25%,purulent discharge,purulent discharge and glans（ genital） swollen rates were 31. 82%and 22. 73%,positive rates of Neisseria gonococcus smear,Neisseria gonococcus culture and oxidase test were27. 27%,45. 45% and 50%,respectively. The treatment efficacy of observation group was better than that of control group,with significant difference（ P�

关 键 词：单纯性淋病 头孢哌酮舒巴坦 剂量 

分 类 号：R759.2[医药卫生—皮肤病学与性病学]