胃溃疡患者合并ST段抬高型心肌梗死溶栓及介入治疗后再灌注损伤程度差异及其机理探讨  

Study on the degree of reperfusion injury after thrombolysis and interventional therapy in patients with gastric ulcer with ST segment elevation myocardial infarction

作　　者：孙文恒[1] 武传佳[2] 

机构地区：[1]吉林市中心医院心血管内科,吉林省吉林市132000 [2]吉林市中心医院消化内科,吉林省吉林市132000

出　　处：《中国心血管病研究》2017年第3期252-255,共4页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨ST段抬高型心肌梗死（STEMI）合并胃溃疡溶栓及介入治疗后缺血再灌注损伤程度的差异及其机理。方法收集2014—2016年在吉林中心医院以及北华大学附属医院心内科及消化内科在院患者病例，试验分为GU（胃溃疡）组和对照组各40例，疗程为2周。结果①两组人群经比较显示，经冠脉介入治疗及溶栓治疗的GU组患者，心肌超氧化物歧化酶（SOD）（390±17）U／g、过氧化氢酶（CAT）（1399±90）KU／L、磷酸肌酸激酶（CK）（500±50）U／L的活性均优于对照组：磷酸肌酸激酶CK（758±20）U／L，心肌超氧化物歧化酶SOD（351±18）U／g，过氧化氢酶CAT（1100±30）KU／L，P〈0．05。②GU组提示胃泌素升高（49．56±11．49）ng／L可以改善患者的缺血再灌注损伤情况，而其在降低心肌酶水平（500±50）U／L方面疗效也优于对照组。结论胃泌素可以有效缓解ST段抬高型心肌梗死患者心肌缺血再灌注损伤。Objective Based on the ST elevation myocardial infarction（STEMI ） patients with ST segment elevation myocardial infarction patients with gastric ulcer and non gastric ulcer （control group ） were observed. To investigat the differences of ischemia reperfusion injury and its mechanism of thrombolysis and interventional therapy the two groups of after of differences were summed up. Methods The patients admitted in Jilin Central Hospital and Department of Cardiology and Affiliated Hospital of Beihua University during 2014-2016 were divided into GU（gastric ulcer, n=40） group and control group（n=40）, and two groups were accepted the same basic treatment for 2 weeks. Results （1）The two groups by comparison showed that GU patients with myocardial coronary artery interventional therapy and thrombolytic therapy of superoxide dismutase （SOD） （390±17）U/g, catalase （CAT） （1399±90）KU/L, ereatine kinase（CK）（500±50）U/L, showed no significant difference in the activity, and better than the control group CK （758±20）U/L, SOD （351±18）U/g, CAT （1100±30）KU/L, P〈0.05. （2）GU group showed increased gastrin （49.56±11.49 ）ng/L can ameliorate ischemia reperfusion injury, and the decrease of myocardial enzyme level （500±50）U/L effects are better than the control group. Conclusion Gastrin can effectively alleviate myocardial ischemia reperfusion injury in patients with ST segment elevation myocardial infarction.

关 键 词：胃溃疡 胃泌素 ST段抬高心肌梗死 再灌注损伤 心肌保护 

分 类 号：R542.22[医药卫生—心血管疾病]