巨噬细胞在支气管哮喘中的作用及研究进展  

The role of macrophages in bronchial asthma and research progress

作　　者：严茜[1] 张建勇[1] 贺仁忠[1] 

机构地区：[1]遵义医学院附属医院呼吸二科,563003

出　　处：《国际呼吸杂志》2017年第5期379-382,共4页International Journal of Respiration

基　　金：贵州省教育厅自然科学资助项目（黔教合协同创新字[2013]07号）;贵州省科学技术基金项目（黔科合J字[2007]2218号）

摘　　要：受微环境变化的影响，巨噬细胞分为经典激活的巨噬细胞（M1）和非经典激活的巨噬细胞（M2）。M1型巨噬细胞可释放如肿瘤坏死因子α（TNF-α）和IL-1B等促炎因子加重炎症反应，也可因极化的增多发挥抗炎作用。M2型巨噬细胞分为M2a、M2b和M2c3种亚型，M2a及M2b型巨噬细胞主要产生炎性细胞因子如IL-4和IL-13，M2c型巨噬细胞主要产生抗炎细胞因子如IL10并有很强的吞噬功能。细胞因子、趋化因子和免疫调节细胞影响着M1型和M2型巨噬细胞的平衡。巨噬细胞不同的极化在支气管哮喘发生与发展中起到重要的作用。Affected by microenvironment change macrophages can be divided into classical activated macrophages （M1） and nonclassical activated maerophages （M2）. M1 macrophages can release such as TNF-α and IL-1β proinflammatory factor to aggravate inflammation, meanwhile the increased polarization can play a role of anti-inflammatory. M2 macrophages are divided into M2a, M2b and M2c. M2a and M2b macrophages mainly produce inflammatory cytokines such as IL-4 and IL-13, M2c type has a strong phagocytosis and it mainly produce anti-inflammatory cytokines such as IL-10. Cytokines and chemokines and immune regulating cell affects the balance of the M1 and M2 macrophages. The different polarization of macrophages play an important role in bronchial asthma. Now the related research of macrophages and bronchial asthma were reviewed as follows.

关 键 词：巨噬细胞 支气管哮喘 作用 极化 

分 类 号：R562.25[医药卫生—呼吸系统]