基于微气泡的超声分子影像探针及其研究进展  

Progress in ultrasound molecular imaging probe based on microbubbles

作　　者：段磊[1,2] 张宇璠 顾宁[1] 

机构地区：[1]东南大学生物电子学国家重点实验室,江苏省生物材料与器件重点实验室,生物科学与医学工程学院,江苏南京210009 [2]南京医科大学基础医学院生物医学工程系,江苏南京211166

出　　处：《南京医科大学学报（自然科学版）》2017年第2期129-138,共10页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：微气泡是超声成像的传统造影剂,从而也成为超声分子成像中最重要的一类探针载体,多模态、多功能、智能化是微气泡类分子探针的发展趋势。近年来一批设计新颖、功能多样的微气泡类分子探针陆续出现,文章在阐述传统微气泡分子探针发展状况的基础上,对融合多种成像方式的多模态微气泡分子探针、诊疗一体化的多功能微气泡分子探针、由特殊病理环境触发的刺激响应型超声分子探针及组织穿透力更强的纳米尺度超声分子探针,在设计思路及研究现状等方面进行了综述。Objective：Microbubble is a kind of traditional contrast agent for ultrasound imaging and also one of the most important probe carriers for ultrasound molecular imaging. The developing trend of molecular probes on microbubbles is to multimodal,multifunctional and intelligent. Now there have been lots of novel and multifunctional molecular probes developed based on microbubbles in recent years. This review summarized the design and application of different types of ultrasound molecular probes. It includes multimodal molecular probes of various imaging modes,multifunctional molecular probes of integration of diagnosis and therapy,stimulated response ultrasound molecular probes triggered by special pathological conditions and enhanced tissue penetration ultrasound molecular nano-probes.

关 键 词：分子影像探针 超声造影剂 微气泡 多模态 诊疗一体化 

分 类 号：R318.08[医药卫生—生物医学工程]