脂联素基因多态性与南京汉族高血压脑出血易感性关系研究  

Adiponectin gene polymorphisms in the susceptibility of hypertensive cerebral hemorrhage

作　　者：陆飞宇[1] 王文宏[2] 王宏[2] 万兴[3] 陈陆馗[2] 

机构地区：[1]南通大学附属南京江北人民医院神经外科,江苏南京210048 [2]东南大学附属中大医院神经外科,江苏南京210023 [3]金华市中心医院神经外科,浙江金华321000

出　　处：《南京医科大学学报（自然科学版）》2017年第2期212-216,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省自然科学基金资助(BK2010419)

摘　　要：目的:探讨人血脂联素(adiponectin,APN)基因单核苷酸多态性与中国南京地区人群高血压脑出血(hypertensive intracerebral hemorrhage,HICH)的相关性。方法:利用SNa Pshot法检测APN中rs2241766、rs1501299、rs17300539和rs266729的基因型及等位基因在150例HICH患者及150例正常健康人中的分布特征。结果:1rs266729位点的GG基因型和G等位基因在病例组和对照组的分布频率具有明显统计学差异(P<0.05);2rs266729位点的GG基因型的HICH病危险度是CC基因型的2.623倍(95%CI:1.282~5.366;P=0.008),校正后仍为HICH的危险因素;3rs2241766、rs1501299、rs17300539位点与HICH的发病风险均没有关联。结论:ADIPOQ基因的rs266729基因多态性与南京地区汉族人群HICH的易感性相关;rs266729位点的GG基因型和G等位基因可能增加南京地区汉族人群HICH的发病风险。Objective：Some adiponectin gene polymorphisms were associated with the risk of many inflammatory diseases. This study was designed to investigate the relationship between single nucleotide polymorphisms in adiponectin genes and hypertensive intracerebral hemorrhage in a Chinese population. Methods：SNa Pshot was adopted to detect the adiponectin genotypes and allele distributions of rs2241766,rs1501299,rs17300539 and rs266729 in 150 patients with hypertensive intracerebral hemorrhage and 150 healthy controls. Results：The frequency distributions of GG genotype and G allele of rs266729 locus were statistically significantly different between the patients and the controls. The hypertensive intracerebral hemorrhage risk of GG genotype of rs266729 locus was2.623 times higher than that of CC genotype（95% confidence interval,1.282-5.366;P =0.008）. This difference retained significant using a logistic regression after multivariate adjustment for the other possible confounders. However,the risk of hypertensive intracerebral hemorrhage was not associated with rs2241766,rs1501299 and rs17300539 locus. Conclusion：Rs266729 gene polymorphism of adiponectin gene is related to hypertensive intracerebral hemorrhage. GG genotype and G allele of rs266729 locus may increase the risk of hypertensive cerebral hemorrhage in a Chinese population.

关 键 词：高血压脑出血 脂联素基因 单核苷酸 多态性 

分 类 号：R544.1[医药卫生—心血管疾病]