妊娠早期甲状腺激素及尿碘参考值范围  

Investigation on reference ranges of thyroid hormones and urine iodine in early pregnancy

作　　者：武萌[1] 韩建华[2] 蔡洁[1] 张惠迪[1] 胡贻椿[1] 单莹[3] 马良坤[3] 杨丽琛[1] 杨晓光[1] 

机构地区：[1]中国疾病预防控制中心营养与健康所 国家卫生计生委微量元素营养重点实验室,北京100050 [2]中国医学科学院北京协和医院检验科 [3]中国医学科学院北京协和医院妇产科

出　　处：《卫生研究》2017年第2期287-290,共4页Journal of Hygiene Research

基　　金：联合国儿童基金会项目

摘　　要：目的建立妊娠早期甲状腺激素参考值范围及适宜的尿碘参考值范围。方法选择北京协和医院产科门诊进行常规产检的368例妊娠早期妇女作为研究对象,采用全自动化学发光免疫分析仪测定血清甲状腺激素,采用电感耦合等离子体质谱仪测定随机尿碘浓度,参考值范围采用双侧限值(P2.5~P97.5)表示。结果妊娠早期甲状腺激素参考值范围:血清游离三碘甲状腺原氨酸为3.74~5.88 pmol/L,血清游离甲状腺素为12.54~20.15 pmol/L;血清促甲状腺激素为0.12~3.48 mU/L。个体适宜尿碘参考值范围为31~543μg/L。结论基于实验室检测结果,建立了妊娠早期甲状腺激素参考值范围及适宜的尿碘参考值范围。Objective To establish the reference ranges of serum thyroid hormones and urine iodine in early pregnancy. Methods The study included 368 early pregnant women who underwent their routine antenatal care in Obstetric Clinic of Peking Union Medical College Hospital. The level of serum thyroid hormones was tested by automatic chemiluminescence immunoassay analyzer. The value of urine iodine was tested by inductively coupled plasma mass spectrometry. The reference ranges were decided by twoside limits（the 2.5th and 97.5th percentile values）. Results The reference ranges of serum thyroid hormones in early pregnancy： FT3 3.74 - 5.88 pmol/L, FT4 12.54 - 20.15 pmol/L, TSH 0.12 - 3.48 mU/L. The reference ranges of individual urinary iodine concentration was 31 - 543 μg/L. Conclusion The reference ranges of serum thyroid hormones and individual urinary iodine in early pregnancy are established based on laboratory testing results.

关 键 词：妊娠早期 甲状腺激素 尿碘 参考值范围 

分 类 号：R714.15[医药卫生—妇产科学] R153.1[医药卫生—临床医学]