失血性休克因素对猪罗库溴铵药代动力学的影响  

Effect of hemorrhagic shock factor on pharmacokinetics of rocuronium in pigs

作　　者：曹惠鹃[1] 刘妹女 陈克研[1] 张铁铮[1] 周锦[1] 

机构地区：[1]沈阳军区总医院麻醉科,110016 [2]河北省人民医院麻醉科,石家庄市050051

出　　处：《中华麻醉学杂志》2017年第1期81-83,共3页Chinese Journal of Anesthesiology

摘　　要：目的 评价失血性休克因素对猪罗库溴铵药代动力学的影响.方法 清洁级巴马小型猪16头,3～5月龄,雌雄不拘,体重22～ 25 kg,采用随机数字表法分为2组（n=8）：对照组（C组）和失血性休克组（HS组）.C组耳缘静脉注射罗库溴铵3.78 mg/kg,HS组采用容量控制法建立失血性休克模型：经15 min自左股动脉匀速放血约40％血容量（血容量30 ml/kg）.模型制备成功后经耳缘静脉注射罗库溴铵3.78 mg/kg.分别于静脉注射罗库溴铵后即刻、2、4、7、10、15、20、30、60、120、180、240、300、360和420 min时,采集颈内静脉血样,采用高效液相色谱-二级质谱联法测定血浆罗库溴铵浓度,并计算其药代动力学参数.结果 与C组比较,HS组注射罗库溴铵后20、60 ～ 420 min时血药浓度升高,消除半衰期和平均驻留时间延长,血浆-效应室平衡速率常数降低（P＜0.05）,最大血药浓度和药-时曲线下面积差异无统计学意义（P＞0.05）.结论 失血性休克猪罗库溴铵的消除过程减慢.Objective To evaluate the effect of hemorrhagic shock factor on the pharmacokinetics of rocuronium in pigs.Methods Sixteen pathogen-free Bama miniature pigs of both sexes,aged 3-5 months,weighing 22-25 kg,were divided into 2 groups （n=8 each） using a random number table：control group （group C） and hemorrhagic shock group （group HS）.In group C,rocuronium 3.78 mg/kg was injected via the auricular vein.In group HS,the animals were subjected to volume-controlled hemorrhage,about 40% of blood volume was withdrawn from the left femoral artery over 15 min （30 ml/kg）,and rocuronium 3.78 mg/kg was injected via the auricular vein after the model was successfully established.At 0,2,4,7,10,15,20,30,60,120,180,240,300,360 and 420 min after rocuronium injection,blood samples were collected from the internal jugular vein for determination of the plasma concentration of rocuronium by high-performance liquid chromatography-tandem mass spectrometry.The pharmacokinetic parameters of rocuronium were calculated.Results Compared with group C,the plasma concentration of rocuronium was significantly increased at 20 and 60-420 min after rocuronium injection,the elimination half-life and mean residence time were prolonged,and the plasma effect-site equilibration rate constant was decreased in group HS （P〈0.05）.There was no significant difference in the maximal concentration and area under the concentration-time curve between the two groups （P〉 0.05）.Conclusion The elimination of rocuronium is slower in a pig model of hemorrhagic shock.

关 键 词：休克 出血性 雄甾烷醇类 药代动力学 

分 类 号：R965[医药卫生—药理学]