中药复方适度调节原理与中药复方新药转化中的药理学问题  

Moderation-integrated-balance presupposition of Chinese medicine compound and pharmacological problems in traditional Chinese drug research

作　　者：赵军宁[1] 

机构地区：[1]四川省中医药科学院,四川省中医药转化医学中心,国家中医药管理局中药质量生物评价重点研究室,四川省道地药材系统开发工程技术研究中心,中药品质评价与创新中药研究四川省重点实验室,四川成都610041

出　　处：《中国中药杂志》2017年第5期836-843,共8页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金面上项目(81470180;81073047);国家重点基础研究发展计划(973)项目(2009CB522801);国家科技支撑计划项目(2012BAI29B10);国家"重大新药创制"科技重大专项(2015ZX09501004-001-005;2011ZX09401-304);四川省科技支撑计划项目(2013sz0115)

摘　　要：该文在概述中药复方作用特点、作用原理研究现状的基础上,首次提出中药复方适度调节原理(moderation-integrated-balance presupposition)新假说,并对中药复方新药转化中的药理学问题作相关讨论,对于加快中药复方新药转化、构建适合中药特点的新药创新与审评体系具有重要价值。The moderation-integrated-balance presupposition （MIBP） of Chinese medicine compound was first proposed in this paper based on the review of function characteristics and action principles of Chinese medicine compound. Furthermore, the pharmacological problems of traditional Chinese drug research were discussed in details. The results were of important value in accelerating the transformation of traditional Chinese medicine compound, and constructing the new drug innovation and review system for traditional Chinese medicine.

关 键 词：中药复方 适度调节原理 药理作用 中药新药 转化医学 

分 类 号：R28[医药卫生—中药学]