三七总皂苷对线粒体调控作用的研究进展  

Research progress on regulation effect of Panax notoginseng saponins on mitochondria

作　　者：杨子平[1] 包怡敏[1] 

机构地区：[1]上海中医药大学基础医学院,上海201203

出　　处：《中国中药杂志》2017年第5期870-874,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81303256;81202945)

摘　　要：线粒体是细胞关键的能量来源,在能量合成与释放、细胞功能维持方面具有重要作用。三七总皂苷作为中药三七中最重要的活性成分,具有抗血栓形成、扩血管、降血压、抗炎、抗氧化等作用。国内外研究表明,三七总皂苷参与调节线粒体能量代谢、氧化应激、生物合成、凋亡与自噬及膜通道状态等,故线粒体是三七总皂苷生物活性的重要靶点。该文就三七总皂苷对线粒体的调控作用做一综述。Mitochondria is the key energy source of cells and plays an important role in energy synthesis and release, and mainte- nance of cellular functions. As the most important active ingredients in Chinese medicine pseudo-ginseng, Panax notoginseng saponins （PNS） have pharmacological effects on protecting against thrombosis, dilating blood vessels, lowering the blood pressure, anti-inflam- mation, and antioxidant, etc. Domestic and foreign studies have shown that PNS participates in regulating mitochondrial energy metabo- lism, oxidative stress, biosynthesis, apoptosis, mitophagy and the status of membrane channels. Therefore, the mitochondria is one of the important targets of PNS. In this paper, the regulation effects of P. notoginseng saponins on mitochondria were reviewed.

关 键 词：三七总皂苷 线粒体 能量代谢 氧化应激 线粒体ATP敏感性钾通道 线粒体自噬 线粒体膜通透性转换孔 

分 类 号：R285[医药卫生—中药学]