中药“毒与效”整合分析的研究进展和前沿分析  

Research progress and frontier of integrated analysis of “toxicity” and “effect” of Traditional Chinese Medicine

作　　者：彭成[1] 肖小河[2] 李梢[3] 程永现[4] 孟庆峰[5] 郭淑贞[5] 高伟[5] 张凤珠[5] 韩立炜[5] 裴瑾[1] 李芸霞[1] 谢晓芳[1] 张若琪[1] 赵萱[1] 

机构地区：[1]成都中医药大学,成都611137 [2]中国人民解放军第302医院,北京100039 [3]清华大学,北京100084 [4]中国科学院昆明植物研究所,昆明650201 [5]国家自然科学基金委员会,北京100085

出　　处：《中国科学基金》2017年第2期176-183,共8页Bulletin of National Natural Science Foundation of China

摘　　要：本文针对国内外高度关注的中药"毒""效"的热点问题,诠释了中药"毒""效"的科学内涵与相互关系,总结了中药"毒""效"物质结构多样、毒性表现多种、毒性可以控制的基本特点,深入分析了中药"毒""效"的研究现状、前沿热点及发展趋势,凝练了中药"毒""效"的科学问题是毒效物质基础、毒效作用机制、控毒增效原理研究,并进一步提出了中药"毒""效"整合分析的意义、原则和路径,以期为建立符合国际规范和中医药特点的中药安全性有效性科学评价体系提供理论、方法及规范。Focusing on the worldwide hot topic--＂toxicity＂ and ＂effect＂ of Traditional Chinese medicine, the paper discusses the scientific connotation and mutual relations of ＂toxicity＂ and ＂effect＂ of TCM, summarizes the basic characteristics including diverse material structure of ＂toxicity＂ and ＂effect＂ of TCM, various toxic manifestations, and controlled toxicity. Then the research status, hot topic and development tendency are analyzed, and scientific problems are put forward including ＂toxicity＂ and ＂effect＂ material basis study, toxic effect mechanism study, and study on principle of controlling toxicity and enhancing efficiency. At last, the meaning, principles and methods of integrated analysis of ＂toxicity＂ and ＂effect＂ of Traditional Chinese medicine are further proposed in order to provide theory, methods and standard for the establishment of Chinese medicine safety and effectiveness evaluation system compliance with international norms and characteristics of Chinese medicine.

关 键 词：中药 毒性 功效 有毒中药 物质基础 作用机制 增效减毒原理 整合分析 

分 类 号：R285.1[医药卫生—中药学]