ROC曲线评估血清C反应蛋白、白细胞诊断小儿上呼吸感染临床价值  

Clinical Values of Serum CRP and WBC in Diagnosis of Upper Respiratory Infection in Children by ROC Curve

作　　者：王亚旭[1] 

机构地区：[1]天津市黄河医院儿科,天津300110

出　　处：《湖北民族学院学报（医学版）》2017年第1期31-33,共3页Journal of Hubei Minzu University(Medical Edition)

摘　　要：目的探讨血清C反应蛋白(CRP)和白细胞(WBC)总数诊断小儿上呼吸感染(URI)的临床价值。方法选取天津市黄河医院儿科2015年10月—2016年10月收治并确诊的URI患儿36例(病例组)和同期儿童保健科健康小儿36例(对照组)为研究对象。免疫荧光法检测两组小儿血清CRP浓度,血细胞分析仪检测两组小儿外周血WBC总数,应用受试者工作特征曲线(ROC)评价CRP和WBC诊断小儿URI的敏感性、特异性及ROC曲线下面积(AUC)。结果病例组患儿血清CRP和WBC显著高于对照组(P<0.05);采用血清CRP诊断小儿URI敏感性为71.4%(95%CI:58.6-84.6),特异性为88.5%(95%CI:73.3-96.8),AUC=0.91(95%CI:0.84-0.97);WBC诊断小儿URI敏感性为69.4%(95%CI:51.9-83.7),特异性为58.3%(95%CI:40.7-74.5),AUC=0.67(95%CI:0.53-0.79)。结论小儿URI血清CRP及WBC明显升高,CRP可作为辅助诊断URI的血清学标志物。Objective To evaluate the clinical values of serum CRP and WBC in diagnosis of upper respiratory infection（ URI） in children by ROC curve. Methods Thirty- six children with URI（ Case Group）and 36 healthy children（ Control Group） were recruited in this study from Oct 2015 to Oct 2016 in Tianjin Huanghe Hospital. The serum level of CRP and WBC was test by immunofluorescence assay and blood cell analyzer. The diagnosis sensitivity,specificity and AUC for URI were analyzed by ROC curve. Results The serum level of CRP and WBC in the Case Group was higher than that in the Control Group（ P〈0. 05）. The diagnosis sensitivity,specificity and AUC were 71. 4%（ 95% CI： 58. 6- 84. 6）,88. 5%（ 95% CI： 73. 3- 96. 8） and AUC = 0. 91（ 95% CI： 0. 84- 0. 97） for serum CRP and 69. 4%（ 95% CI：51. 9- 83. 7）,58. 3%（ 95% CI： 40. 7- 74. 5）,AUC = 0. 67（ 95% CI： 0. 53- 0. 79） for WBC,respectively. Conclusion The serum CRP and WBC were elevated in children with URI. The CRP can be a potential biomarker for URI diagnosis.

关 键 词：C反应蛋白 小儿 诊断试验 上呼吸道感染 

分 类 号：R725.1[医药卫生—儿科]