普罗布考联合瑞舒伐他汀钙对不稳定型心绞痛患者血脂代谢异常的临床效果  

Clinical effect of probucol combined with rosuvastatin calcium on lipid metabolism abnormality in patients with unstable angina pectoris

作　　者：张战文[1] 陈晖[1] 王宝玉[1] 邱春光[2] 

机构地区：[1]郑州大学附属郑州中心医院急诊心内科,450007 [2]郑州大学第一临床学院,450052

出　　处：《中国实用医刊》2017年第5期4-6,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨普罗布考联合瑞舒伐他汀钙对不稳定型心绞痛患者血脂代谢的影响。方法将160例不稳定型心绞痛患者随机分为对照组（普罗布考组，50例）、瑞舒伐他汀钙组（50例）与联用组（普罗布考联用瑞舒伐他汀钙组，60例），三组分别给予相应治疗3个月，观察三组患者治疗前后血脂水平的变化。结果治疗前三组患者血脂水平等比较差异未见统计学意义（P〉0．05）。治疗3个月后三组三酰甘油、总胆固醇、低密度脂蛋白胆固醇均下降，联用组及瑞舒伐他汀钙组均低于对照组（P〈0．05），联用组低于他汀组（P〈0．05）；高密度脂蛋白胆固醇水平明显升高（P〈0．05）。联用组不良反应略多，但三组不良反应发生率比较差异未见统计学意义。结论普罗布考联合瑞舒伐他汀钙能明显降低不稳定型心绞痛患者血脂水平，未增加不良反应，是安全有效的。Objective To observe the effect of probucol combined with rosuvastatin calcium on serum lipid metabolism abnormality in patients with unstable angina pectoris. Methods One hundred and sixty patients with unstable angina pectoris were randomly divided into the control group （probucol group, 50 cases）, statin group（50 cases） and the combined group（60 cases）, which have been given medication for 3 months respectively. Blood lipid（TG, TC, LDL-C, HDL-C） were measured before and after treatment. Results The differences of blood lipid（TG, TC, LDL-C, HDL-C） levels before treatment in the three groups were not significant（P 〉 0. 05）. After treatment, TC, TG, LDL-C levels in the patients of combined and statin group were significantly lower than those in the control group（ P 〈 0. 05 ）, combined group had lower TC, TG, LDL-C levels than rosuvastatin group, and TC, TG, LDL-C in both groups were lower than those in control group （ P 〈 0. 05 ）, the HDL-C levels were higher than those in control group （ P 〈 0.05 ）. Adverse reactions in combined group with a little more, but there was no significant difference among the three groups. Conclusions Probucol combined with rosuvastatin calcium is effective and safe in the treatment of unstable angina pectoris with lipid metabolism abnormality.

关 键 词：不稳定型心绞痛 普罗布考 瑞舒伐他汀钙 血脂代谢 

分 类 号：R541.4[医药卫生—心血管疾病]