培美曲塞联合顺铂化疗对老年非小细胞癌患者外周血淋巴细胞表型变化的影响  

Pemetrexed and cisplatin for elderly patients with non-small cell carcinoma of peripheral blood lymphocyte phenotype changes

作　　者：王纬久 

机构地区：[1]山东省新泰市第三人民医院内四科,271219

出　　处：《中国实用医刊》2017年第5期22-25,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨培美曲塞联合顺铂化疗方案对老年非小细胞癌患者外周血淋巴细胞表型变化的影响。方法在2013年2月至2015年10月老年非小细胞肺癌患者中选取50例，均接受培美曲塞联合顺铂化疗治疗，治疗时间在2个疗程以上，对治疗前后患者外周血CD3^＋、CD4^＋、CD8^＋、CD16^＋56^＋、CD19^＋细胞及CD4^＋/CD8^＋水平进行检测记录。结果化疗前后CD8^＋、CD19^＋、CD3^＋比较并无明显变化，但CD4^＋、CD4^＋/CD8^＋、CD16^＋56^＋较化疗前均有显著上升（P〈0.05）。结论采用培美曲塞联合顺铂治疗老年非小细胞肺癌患者，可在一定程度上促进患者机体免疫功能的重建和增强，有利于改善预后，特别是对于晚期患者，此种重建效果更为明显。Objective To investigate the effect of pemetrexed combined with cisplatin chemotherapy on elderly patients with non-small cell carcinoma of peripheral blood lymphocyte phenotype change.Methods Fifty elderly patients with non-small cell lung cancer from February 2013 to October 2015 were selected, all of them were treated by chemotherapy for training pemetrexed in combination with cisplatin; the treatment period lasted two or more cycles. CD3^＋ , CD4^＋ , CD8^＋ , CD16^＋ 56^＋ , CD19^＋ cells and CD4^＋ / CD8^＋ levels in peripheral blood before and after treatment were recorded.Results Before and after chemotherapy, CD8^＋ , CD19^＋ , CD3^＋ compared with no significant change, but CD4^＋ , CD4^＋ / CD8^＋ , CD16^＋ 56^＋ than before chemotherapy were significantly increased （P〈0.05）.Conclusion Using pemetrexed combined with cisplatin treatment in elderly patients with non-small cell lung cancer, in some extent, promote reconstruction in patients with immune function and enhancements will help to improve the prognosis, and the reconstruction effects are more significant for patients with advanced disease.

关 键 词：老年非小细胞肺癌 培美曲塞 顺铂 淋巴细胞表型 

分 类 号：R734.2[医药卫生—肿瘤]