Is Chinese Herbal Medicine Effective for Elderly Isolated Systolic Hypertension? A Systematic Review and Meta-Analysis  

作　　者：CAO Yu LIU Long-tao WU Min 

机构地区：[1]Department of Cardiovascular Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences [2]Gerontology Medical Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences

出　　处：《Chinese Journal of Integrative Medicine》2017年第4期298-305,共8页中国结合医学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.81102721 and No.81202805);a Planned Technologic Item of State Administration of Traditional Chinese Medicine(No.04-05LP30);Chinese National Scientific Fund for Post-Doctor(No.20070410622);its Special Aid Item(No.201003226);the Key Technologies R&D Program of Shandong Province,China(No.2010 GSF 10289)

摘　　要：To study the efficacy of Chinese medicine (CM) on isolated systolic hypertension. Seven electronic databases were searched for randomized controlled trials (RCTs) published until August 2015. Subgroup analyses and meta-analysis were performed to assess the efficacy and safety of the included studies. A total of 24 studies, including 2,096 patients (1,058 patients in the intervention group and 1,038 in the control group), were evaluated in the final analysis. Compared with a conventional therapy used alone, CM as additional intervention was more effective on systolic blood pressure [mean difference (MD)=-0.66, 95% confidence interval (CI)=(-0.97,-0.36), P < 0.00001] and significantly diminished the pulse pressure [MD=-7.49, CI=(-12.69,-2.29), P < 0.00001]. However it showed no additional benefit on diastolic blood pressure [MD=1.16, CI=(0.02, 2.29), P=0.87]. Adverse events were not explicitly reported in most RCTs. CM might be a promising approach for the elderly with isolated systolic hypertension, while the evidence for CM employed alone was insufficient. Considering the inherent limitations of the included studies, larger high-quality RCTs with extensive follow-up should be performed to validate our findings in the future.To study the efficacy of Chinese medicine (CM) on isolated systolic hypertension. Seven electronic databases were searched for randomized controlled trials (RCTs) published until August 2015. Subgroup analyses and meta-analysis were performed to assess the efficacy and safety of the included studies. A total of 24 studies, including 2,096 patients (1,058 patients in the intervention group and 1,038 in the control group), were evaluated in the final analysis. Compared with a conventional therapy used alone, CM as additional intervention was more effective on systolic blood pressure [mean difference (MD)=-0.66, 95% confidence interval (CI)=(-0.97,-0.36), P < 0.00001] and significantly diminished the pulse pressure [MD=-7.49, CI=(-12.69,-2.29), P < 0.00001]. However it showed no additional benefit on diastolic blood pressure [MD=1.16, CI=(0.02, 2.29), P=0.87]. Adverse events were not explicitly reported in most RCTs. CM might be a promising approach for the elderly with isolated systolic hypertension, while the evidence for CM employed alone was insufficient. Considering the inherent limitations of the included studies, larger high-quality RCTs with extensive follow-up should be performed to validate our findings in the future.

关 键 词：Chinese herbal medicine isolated systolic hypertension META-ANALYSIS systematic review randomized controlled trial 

分 类 号：R259[医药卫生—中西医结合]