薄膜-超声法制备双烟酸姜黄素酯纳米粒的辅料配比研究  

Excipient Formula Research of Nicotinate-Curcumin nanoparticles Prepared by Film Ultrasonic Method

作　　者：郭静一[1] 汪鹏[1] 胡曼[1] 何群[1,2] 林丽美[1,2] 廖端芳[1,2] 

机构地区：[1]湖南中医药大学药学院,长沙410208 [2]湖南省药学"十二五"重点学科建设基地,长沙410208

出　　处：《中国药学杂志》2017年第6期462-467,共6页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(81173047);湖南省自然科学基金资助项目(12JJ5068)

摘　　要：目的优选薄膜-超声法制备双烟酸姜黄素酯固体脂质纳米粒的辅料配比。方法采用HPLC测定双烟酸姜黄素酯的含量,以双烟酸姜黄素酯固体脂质纳米粒的包封率为评价指标,通过三因素三水平Box-Bebnken响应面设计试验法筛选纳米粒辅料中硬脂酸、卵磷脂的用量及聚山梨酯-80的浓度,并确定最优处方辅料配比。结果最佳处方辅料配比为硬脂酸80 mg,卵磷脂150 mg,聚山梨酯-80(0.6%)20 m L,所得烟酸姜黄素固体脂质纳米粒包封率达65%,平均粒径为190 nm。结论用星点设计试验优化后制剂处方的双烟酸姜黄素酯固体脂质纳米粒最优处方辅料配比适合于制备双烟酸姜黄素酯固体脂质纳米粒。OBJECTIVE To optimize the fihn-ultrasonic technique for preparing nicotinate-curcumin nanoparticles. METHODS An HPLC method was established for determination of nicotinate-curcumin. Using the entrapment efficiency of nieoti- nate-curcumin as the evaluation indicator, the optimum excipient formula was selected through the Box-Bebnken reponse surface design of three factors （ amounts of nicotinate-curcumin and lecithin and concentration of tween-80） at three levels. RESULTS With the established optimal formula, ie 80 mg stearic acid, 150 mg lecithin and 20 mL tween-80 （0. 6% ）, the entrapment efficiency of nicoti- nate-curcumin approached 65%. The mean particle size was 190 nm. CONCLUSION The nicotinate-curcumin nanoparticles prepared by the film ultrasonic technique optimized by central composite design test have high entrapment efficiency, indicating that the technique is feasible.

关 键 词：双烟酸姜黄素酯 固体脂质纳米粒 薄膜-超声法 包封率 

分 类 号：R944[医药卫生—药剂学]