830nm近红外光联合308nm单频准分子光治疗白癜风的临床疗效观察  

The efficacy of 830nm IR-A combined with 308nm monochromatic excimer light for vitiligo

作　　者：徐平[1] 吴平梅 吴钦国[1] 何勤[2] 

机构地区：[1]贵州医科大学第二附属医院皮肤科,贵州凯里556000 [2]贵州医科大学附属医院皮肤科,贵州贵阳550004

出　　处：《临床皮肤科杂志》2017年第4期251-255,共5页Journal of Clinical Dermatology

摘　　要：目的 :探讨830 nm近红外光(IR-A)联合308 nm单频准分子光(MEL)照射对白癜风的治疗效果。方法:选择皮肤科门诊白癜风患者123例,每例患者色素减退面积占全身皮肤总面积≤10%,随机分成3组,分别给予IR-A、MEL及二者联合治疗,每周2次,连续进行12周并作出疗效评价。结果:IR-A与MEL联合治疗组40例,显效率72.5%,高于IR-A组(40例,显效率25.0%)与MEL组(43例,其中3例中途放弃治疗,显效率47.5%),差异均有统计学意义(P均<0.05)。联合治疗组起效的速度较其他2组更快。不良反应为红斑、轻度瘙痒等,其中IR-A组的不良反应最为轻微,可以忽略;MEL组不良反应最重,且消退最慢;联合治疗组不良反应较轻,能很快自行消退。结论:IR-A与MEL联合应用可以提高治疗白癜风效果,起效速度更快,并减轻不良反应。Objective： To investigate the clinical efficacy of 830 nm near infrared ray（IR-A） radiation combined with 308 nm monochromatic excimer light（MEL） for vitiligo. Methods： A total of 123 vitiligo patients with depigmcnted area≤10% of the total skin area were randonfly divided into 3 groups, i.e, IR-A, MEL, and combination of IR-A and MEL treatment. Pa- tients were treated twice weekly for 12 weeks. Result： Treatments with combination of IR-A and MEL yielded significantly higher effective rates than that with either IR-A or MEL alone （effective rates： 72.5% for combination of IR-A and MEL; 25.0% for IR-A; 47.5% for MEL）. In addition, repigmeutation appeared earlier in patients treated with combination of IR-A and MEL than in patients treated with either IR-A or MEL alone. Adverse reactions included e12~thema, mild pruritus and others. IR-A-induced adverse reactions were negligible, while MEL induced severe side effects, which disappeared slowly. In contrast, combination of IR-A and MEL caused mild side effects, which disappeared rapidly and spontaneously. Conclusion： Combination of IR-A and MEL（UVB） can improve the therapeutic efficacy for vitiligo, rapidly induce repigmentation, and re- duce the severity of adverse effects.

关 键 词：830 nm近红外光 308nm单频准分子光 白癜风 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]