SiO_2微球的微结构表面组成修饰及其蛋白质/细胞响应  

Chemical Modification and Protein/Cellular Responses on Surfaces of SiO_2 Microspheres

作　　者：黄晓笑 程逵[1] 翁文剑[1] 

机构地区：[1]浙江大学材料科学与工程学院,杭州310027

出　　处：《硅酸盐学报》2017年第4期510-517,共8页Journal of The Chinese Ceramic Society

基　　金：国家自然科学基金(51472216)

摘　　要：采用SiO_2微球构建微结构表面,分别以TiO_2、Al_2O_3、Au对其表面组成进行修饰。研究了在确定表面微结构的条件下,不同组成修饰对蛋白质吸附与细胞响应行为的影响。结果表明:表面组成改变会影响蛋白质的吸附,细胞的初期黏附与蛋白质吸附量有密切的关系;在细胞增殖阶段,除了蛋白质吸附量,蛋白质吸附取向可能也是影响细胞行为的重要因素之一。TiO2, Al2O3 and Au were used to modify the microstructured surfaces constructed by SiO2 microspheres, respectively. The protein adsorption capacity and cell response of the chemically modified surfaces were investigated. The results indicate that the protein adsorption is related to the chemical composition of the surface, the initial adhesion of the cells is closely related to the protein adsorption capacity, and the amount and orientation of protein adsorption both are considered as important factors affecting the cell proliferation.

关 键 词：微结构表面 组成修饰 蛋白黏附 细胞响应 

分 类 号：TB17[生物学—生物工程]