1例米诺环素治疗布鲁氏菌病致急性嗜酸性粒细胞性肺炎的分析  

Minocycline induced acute eosinophilic pneumonia in a patient with brucellosis

作　　者：张斌[1] 刘一[1] 黄婧[1] 任晓蕾[1] 张春燕[1] 陈美芳[2] 冯婉玉[1] 

机构地区：[1]北京大学人民医院药剂科,北京100044 [2]北京大学人民医院感染科,北京100044

出　　处：《中国临床药理学杂志》2017年第6期551-553,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的提醒临床重视米诺环素所致的药物不良反应(ADR)。方法对1例布鲁氏菌病感染患者应用米诺环素治疗时所发生的ADR过程进行分析。结果患者用药至第25天时,出现呼吸道症状、嗜酸性粒细胞增高胸片提示嗜酸性粒细胞性肺炎。在停用米诺环素并经抗过敏治疗13 d后,患者临床症状减轻,嗜酸性粒细胞降至正常。患者于再次服用米诺环素的次日,再次出现嗜酸性粒细胞升高,考虑为米诺环素相关急性嗜酸性粒细胞性肺炎。结论米诺环素引起急性嗜酸性粒细胞性肺炎较为严重,因此应关注患者症状和体征,注意监测全血细胞计数,确保临床用药安全。Objective To remind doctors pay attention to the adverse drug reaction caused by minocycline.Methods Retrospective analysis of a case of brucellosis treated with minocycline.Results The clinical symptoms started after the patient had been taking minocycline for 25 days,and alleviated after the patient withdrawn minocycline and initiating anti-allergic treatment for 13 days.Also,white blood cell and eosinophil recovered to normal.However,after taking minocycline again,fever appeared in the next day,together with eosinophil increased gradually.Thus,we consider acute eosinophilic pneumonia was related to minocycline.Conclusion Although minocycline induced acute eosinophilic granular cell pneumonia is rare,consequence was always serious.Therefore,more attention should be paid during the treatment,such as monitoring the whole blood cell count,concerning the symptoms and physical signs of patients to ensure the safety of medications.

关 键 词：米诺环素 急性嗜酸性粒细胞性肺炎 药物不良反应 

分 类 号：R978.1[医药卫生—药品]