血痛定巴布剂抗炎镇痛作用的药效学研究  

Anti-inflammatory and analgesic effect of Xuetongding cataplasm

作　　者：侯君[1] 窦建卫[2] 李静[1] 刘爱琴[3] 由凤鸣[4] 郑德志[5] 李聃丹[6] 周龙甫[1] 呼永河[1] 

机构地区：[1]成都军区总医院药剂科,成都610083 [2]西安交通大学药学院,西安710061 [3]解放军第452医院眼科,成都610021 [4]成都中医药大学附属医院内分泌科,成都610075 [5]济南军区总医院心外科,济南250031 [6]第三军医大学新桥医院临床药理基地,重庆400037

出　　处：《东南国防医药》2017年第1期8-12,共5页Military Medical Journal of Southeast China

基　　金：国家科技重大专项课题(2014ZX09J14107-03B)

摘　　要：目的评价血痛定巴布剂的抗炎镇痛作用。方法采用炎症、疼痛动物模型,观察血痛定巴布剂的药效作用。结果血痛定巴布剂可显著降低小鼠腹腔毛细血管通透性,可显著降低二甲苯所致耳廓肿胀和小鼠肉芽肿,可显著抑制角叉菜胶所致足趾肿胀;可显著减少醋酸致小鼠扭体次数,对小鼠热刺激所致痛阈值的变化不明显。结论血痛定巴布剂具有明显的抗炎作用,无镇痛作用。Objective To evaluate the anti-inflammatory and analgesic effects of Xuetongding cataplasm. Methods Animal models of inflammation and ache were adopted, and pharmacodynamic actions of Xuetongding cataplasm were observed.Results Xuetongding cataplasm lowered the capillaries permeability distinctly and inhibited xylol-induced mouse ear inflammation and cotton ball-induced mouse granuloma. Xuetongding cataplasm could conspicuously restrain rat foot metatarsus tumid treated by carrageenan,and decreased the twist-reaction stimulated by acetic acid. Thermal stimulation did not change pain threshold significantly.Conclusion Xuetongding cataplasm has obvious anti-inflammatory effects,and no analgesic effects.

关 键 词：血痛定巴布剂 抗炎 镇痛 

分 类 号：R285[医药卫生—中药学]