乙型肝炎患者NLR、PLR的变化及临床意义  

Change and clinical significance of NLR and PLR in patients with hepatitis B

作　　者：吴美玲[1] 鞠瑛[1] 刘成程[1] 成士清[1] 王勇[1] 张炳昌[1] 

机构地区：[1]山东大学附属省立医院临床医学检验部,济南250021

出　　处：《检验医学与临床》2017年第6期749-751,共3页Laboratory Medicine and Clinic

基　　金：国家自然科学基金资助项目(81000731);山东省优秀中青年科学家奖励基金资助项目(B2010YY045)

摘　　要：目的探讨乙型肝炎患者中性粒细胞与淋巴细胞绝对值比值(NLR)、血小板计数与淋巴细胞绝对值比值(PLR)的变化及临床意义。方法收集59例乙型肝炎患者和124例健康志愿者外周血标本,检测血常规和肝功指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)]并进行分析。结果健康对照组与乙型肝炎患者组的NLR中位数分别为1.64、1.77,差异有统计学意义(Z=-2.28,P<0.05),乙型肝炎患者PLR中位数分别为109.00、100.00,差异有统计学意义(Z=-5.80,P<0.05)。乙型肝炎患者根据受试者工作特征曲线选取最佳截点分为低NLR组(NLR<1.36,25例)与高NLR组(NLR≥1.36,34例);低PLR组(PLR<86.17,32例)与高PLR组(PLR≥86.17,27例)。在低NLR组与高NLR组中,GGT中位数分别为34.00、19.50,两组差异有统计学意义(Z=-2.30,P=0.02),而AST、ALT差异无统计学意义(P>0.05);在低PLR组与高PLR组中,AST、ALT和GGT差异均无统计学意义(P>0.05)。结论 NLR、PLR对乙型肝炎患者与健康者的鉴别有一定的价值。Objective To study the change and clinical significance of the neutrophils and lymphocytes absolute value ratio（NLR）,and platelet count and the lymphocyte absolute value ratio（PLR）in the patients with hepatitis B.Methods Peripheral blood specimens of 59 patients with hepatitis B and 124 healthy volunteers were collected for detecting the routine blood and liver indexes[alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,gamma glutamyl transpeptidase（GGT）]and analysis.Results The NLR median in the healthy control group and hepatitis B group was 1.64 and 1.77 respectively,the difference was statistically significant（Z=-2.28,P〈0.05）.The PLR median was 109.00 and 100.00 respectively,the difference was statistically significant（Z=-5.80,P〈0.05）.According to the selected best cutoff point of the ROC curve,the patients with hepatitis B were divided into the low NLR group（NLR1.36,25cases）and high NLR group（NLR ≥1.36,34cases）;low PLR group（PLR86.17,32cases）and high PLR group（PLR≥86.17,27cases）.In the low NLR and high NLR groups,the GGT median was 34.00 and 19.50 respectively.the difference was statistically significant（Z=-2.30,P=0.02）,but AST and ALT medians showed no statistical difference between the two groups（P〉0.05）;in the low PLR and high PLR groups,AST,ALT and GGT medians had no statistical difference between the two groups（P〉0.05）.Conclusion NLR and PLR have a certain value for the identification of patients with hepatitis B and healthy persons.

关 键 词：乙型肝炎 中性粒细胞与淋巴细胞绝对值比值 血小板计数与淋巴细胞绝对值比值 

分 类 号：R512.62[医药卫生—内科学]