两面针碱全合成及活性研究进展  

Research progress on total synthesis and activity of nitidine

作　　者：赵增[1] 陈浩[1] 杨鸟 孙青龑[1] 柳润辉[1] ZHAO Zeng CHEN Hao YANG Niao SUN Qingyan LIU Runhui(Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University,Shanghai 200433 ,Chin)

机构地区：[1]第二军医大学药学院天然药化教研室,上海200433

出　　处：《药学实践杂志》2017年第2期102-107,149,共7页Journal of Pharmaceutical Practice

摘　　要：两面针碱是传统中药两面针根的提取物,属于苯并菲啶类生物碱。研究发现两面针碱具有多种生物活性,对肿瘤、疟疾等多种疾病有效。笔者对两面针碱全合成方法及近年来的活性研究进行综述。Nitidine is a benzophenanthridine alkaloid derived from Zanthorulum nitidum （Roxb.） DC root. Research shows that nitidine displays rich biological activities, such as anti tumor, anti-inflammatory, anti malaria and etc reviewed the progress of the total synthesis methods for nitidine and recent research on bioactivities.

关 键 词：两面针碱 全合成 生物活性 作用机制 

分 类 号：R284.3[医药卫生—中药学]