用紫外导数分光光度法测定复方替米沙坦氨氯地平片的含量  

Determination of amlodipine and telmisartan in the compound tablet by first derivative UV spectrophotometry

作　　者：苏江涛[1] 胡常杰 张汉桥[1] 张梦林[1] 谢卫红[1] 糜志远[1] SU Jiangtao HU Changjie ZHANG Hanqiao ZHANG Menglin XIE Weihong MI Zhiyuan(Biology and Food Engineering College, Hubei University of Technology, Wuhan 430068,Chin)

机构地区：[1]湖北工业大学生物工程与食品学院,湖北武汉430068

出　　处：《药学实践杂志》2017年第2期150-153,共4页Journal of Pharmaceutical Practice

基　　金：湖北省科技厅自然科学基金项目(2015CFB299)

摘　　要：目的测定复方片中替米沙坦和氨氯地平的含量。方法采用紫外导数分光光度法,替米沙坦测定波长为236nm,氨氯地平测定波长为390nm。结果替米沙坦浓度在(4~20)×10^(-3) mg/ml范围内与一阶导数值有良好的线性关系,其标准曲线方程为Y=0.004 3X-0.000 5,R^2=0.999 3;氨氯地平浓度在(10~90)×10^(-3) mg/ml范围内与一阶导数值有良好的线性关系,其标准曲线方程为Y=0.000 3X+0.000 2,R^2=0.999 5。结论该方法具有较好的灵敏度、准确度和精密度;样品检测结果与HPLC法基本一致;是测定复方替米沙坦氨氯地平片含量的一种较好的分析方法。Objective To determine telmisartan and amlodipine assay in the compound tablet. Methods First derivative UV spectrophotometry was used at wavelength 236 nm for telmisartan and 390 nm for amlodipine. Results Telmisartan content has a good linear relationship in the concentration range of （4～ 20） × 10 -3 mg/ml. The standard curve equation is Y= 0. 004 3 X-0. 000 5 and correlation coefficlent R2=0. 999 3. Amlodipine content has a good linear relationship in the concentration range of （10-90） × 10-3 mg/ml. The standard curve equation is Y= 0. 000 3 X＋0. 000 2 and correlation coefficient R2 =0. 999 5. Conclusion The assay results from this method are consistent with the results from HPLC. This procedure provides a specific, accurate and precise method to assay the amlodipine and telmisartan in compound tablet.

关 键 词：紫外导数分光光度法 替米沙坦 氨氯地平 含量测定 

分 类 号：O657[理学—分析化学]