人血白蛋白在危重症患者中临床应用的评价  

Evaluation on the clinical utilization of human serum albumin in ICU patients

作　　者：周婷[1] 杨珍 陆赛花 刘秀凤[1] 张晔[1] 徐峰[1] ZHOU Ting YANG Zhen LU Saihua LIU Xiufeng ZHANG Ye XU Feng(Department of Pharmacy,South Cam- pus, Sixth People＇s Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 201499, China Department of Pharma- cy, Fengxian Hospital, Jinzhou Medical University, Shanghai 201499, China)

机构地区：[1]上海交通大学附属第六人民医院南院药剂科,上海201499 [2]锦州医科大学附属奉贤医院药剂科,上海201499

出　　处：《药学实践杂志》2017年第2期167-170,共4页Journal of Pharmaceutical Practice

基　　金：上海市卫生计生委青年项目(20134y171);上海市医院药学科研基金(2013-YY-01-04)

摘　　要：目的评价重症监护病房(ICU)人血白蛋白(human serum albumin,HSA)合理使用情况,促进HSA的合理应用。方法收集2015年1月1日至2015年12月31日ICU使用HSA患者信息,对HSA使用情况进行统计分析,评价使用的合理性。结果 64例患者使用HSA共计416支,平均用量62.5g;使用HSA主要原因为低蛋白血症(39.1%),其次为脑水肿、颅脑外伤、各型休克及恶性肿瘤等。使用HSA前,患者血清白蛋白水平在25~35g/L的占35.9%,15~25g/L的占56.3%。结论 ICU的HSA使用广泛,涉及多种用途,但存在超适应证使用等不合理使用情况。呼吁相关部门尽快出台HSA使用指南,促使各医疗机构规范使用。Objective To evaluate the utilization of human serum albumin （HSA） in intensive care unit （ICU） to promote rational use of HSA clinically. Methods Data were collected from the patients received HSA therapy during the period of January 1, 2015 to December 31, 2015. The indications and usage of HSA were analyzed statistically. Results 416 bottles of HSA were administered to 64 patients. The average dose was 62.5g per patient. The most popular indication was for hypoproteinemia （39.1%） followed by encephaledema, craniocerehral trauma, shock and tumors. Before the HSA therapy, 36 patients （56.3%） had albumin level of 15-25 g/L and 23 patients （35.9%） of 25 35 g/L. Conclusion HSA is widely used in ICU for different indications. Some misuses still exist. Guidelines for proper use of HSA are needed to guarantee its rational use. HSA should he used strictly following these guidelines.

关 键 词：人血白蛋白 合理应用 评价 危重症患者 

分 类 号：R457[医药卫生—治疗学]